UniProt Accession

 C9JR83_HUMAN; C9JR83 

Genbank Protein ID

 AC024221 

Genbank Nucleotide ID

  

Protein Name

 Structural maintenance of chromosomes protein 4 

Protein Synonyms/Alias

  

Gene Name

 SMC4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
268	GRLNEPIKVLCRRVE	acetylation	[1]
268	GRLNEPIKVLCRRVE	ubiquitination	[1, 2]
293	NRVKMVEKEKDALEG	ubiquitination	[2]
341	IAEMETQKEKIHEDT	ubiquitination	[2]
343	EMETQKEKIHEDTKE	ubiquitination	[2]
349	EKIHEDTKEINEKSN	acetylation	[1]
349	EKIHEDTKEINEKSN	ubiquitination	[2]
389	FIEENKEKFTQLDLE	ubiquitination	[3]
413	HATSKAKKLEKQLQK	ubiquitination	[3]
416	SKAKKLEKQLQKDKE	acetylation	[1]
416	SKAKKLEKQLQKDKE	ubiquitination	[2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0051383; P:kinetochore organization; IEA:Compara.
 GO:0010032; P:meiotic chromosome condensation; IEA:Compara.
 GO:0045132; P:meiotic chromosome segregation; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR003395; RecF/RecN/SMC. 

Pfam

 PF02463; SMC_N 

SMART

  

PROSITE

  

PRINTS