CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043962
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable E3 ubiquitin-protein ligase MYCBP2 
Protein Synonyms/Alias
  
Gene Name
 MYCBP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
174NITINCVKGINARYVubiquitination[1, 2]
259QVKVLGWKDGESTKIubiquitination[1, 2]
313PTPEQEEKALLSSPEubiquitination[3]
972SRAQMCPKHGTDFLEubiquitination[2]
981GTDFLEYKCRYCCSVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1061 AA 
Protein Sequence
XNKTSKENSE QEKDTRVCEH PLSDIVIAGE AAHPLPHTFH RLLQTISDLM MSLPSGSSLQ 60
QMALRCWSLK FKQSDHQFLH QSNVFHHINN ILSKSDDGDS EESFSISIQS GFEAMSQELC 120
IVMCLKDLTS IVDIKTSSRP AMIGSLTDGS TETFWESGDE DKNKTKNITI NCVKGINARY 180
VSVHVDNSRD LGNKVTSMTF LTGKAVEDLC RIKQVDLDSR HIGWVTSELP GGDNHIIKIE 240
LKGPENTLRV RQVKVLGWKD GESTKIAGQI SASVAQQRNC EAETLRVFRL ITSQVFGKLI 300
SGDAEPTPEQ EEKALLSSPE GEEKATSDAD LKEHMVGIIF SRSKLTNLQK QVCAHIVQAI 360
RMEATRVREE WEHAISSKEN ANSQPNDEDA SSDAYCFELL SMVLALSGSN VGRQYLAQQL 420
TLLQDLFSLL HTASPRVQRQ VTSLLRRVLP EVTPSRLASI IGVKSLPPAD ISDIIHSTEK 480
GDWNKLGILD MFLGCIAKAL TVQLKAKGTT ITGTAGTTVG KGVTTVTLPM IFNSSYLRRG 540
ESHWWMKGST PTQISEIIIK LIKDMAAGHL SEAWSRVTKN AIAETIIALT KMEEEFRSPV 600
RCIATTRLWL ALASLCVLDQ DHVDRLSSGR WMGKDGQQKQ MPMCDNHDDG ETAAIILCNV 660
CGNLCTDCDR FLHLHRRTKT HQRQVFKEEE EAIKVDLHEG CGRTKLFWLM ALADSKTMKA 720
MVEFREHTGK PTTSSSEACR FCGSRSGTEL SAVGSVCSDA DCQEYAKIAC SKTHPCGHPC 780
GGVKNEEHCL PCLHGCDKSA TSLKQDADDM CMICFTEALS AAPAIQLDCS HIFHLQCCRR 840
VLENRWLGPR ITFGFISCPI CKNKINHIVL KDLLDPIKEL YEDVRRKALM RLEYEGLHKS 900
EAITTPGVRF YNDPAGYAMN RYAYYVCYKC RKAYFGGEAR CDAEAGRGDD YDPRELICGA 960
CSDVSRAQMC PKHGTDFLEY KCRYCCSVAV FFCFGTTHFC NACHDDFQRM TSIPKEELPH 1020
CPAGPKGKQL EGTECPLHVV HPPTGEEFAL GCGVCRNAHT F 1061 
Gene Ontology
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 
Interpro
 IPR004939; APC_su10/DOC_dom.
 IPR008979; Galactose-bd-like.
 IPR027047; Highwire/Pam/Rpm-1.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF03256; APC10
 PF13639; zf-RING_2 
SMART
 SM00184; RING 
PROSITE
 PS51284; DOC
 PS50089; ZF_RING_2 
PRINTS