UniProt Accession

 QCR7_HUMAN; P14927; E5RJU0; Q6FGD1 

Genbank Protein ID

 X13585; M22348; CR542176; CR542196; M26730; M35761; M26706; M26707; M26700; M26701; AP003465; CH471060; BC005230; BU535281; M37387 

Genbank Nucleotide ID

 CAA31926.1; AAA60238.1; CAG46973.1; CAG46993.1; AAA60235.1; AAA60235.1; AAA60235.1; AAA60235.1; AAA60236.1; AAA60237.1; EAW91749.1; AAH05230.1; AAA60361.1 

Protein Name

 Cytochrome b-c1 complex subunit 7 

Protein Synonyms/Alias

 Complex III subunit 7; Complex III subunit VII; QP-C; Ubiquinol-cytochrome c reductase complex 14 kDa protein 

Gene Name

 UQCRB 

Gene Synonyms/Alias

 UQBP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MAGKQAVSASG	acetylation	[1]
12	QAVSASGKWLDGIRK	ubiquitination	[2, 3]
29	YNAAGFNKLGLMRDD	ubiquitination	[2, 3]
45	IYEDEDVKEAIRRLP	ubiquitination	[4]
72	RALDLNLKHQILPKE	ubiquitination	[5]
78	LKHQILPKEQWTKYE	acetylation	[6]
83	LPKEQWTKYEEENFY	ubiquitination	[5]
96	FYLEPYLKEVIRERK	acetylation	[7]
96	FYLEPYLKEVIRERK	ubiquitination	[5]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 12 12 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Respiratory chain; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 111 AA 

Protein Sequence

Gene Ontology

 GO:0005746; C:mitochondrial respiratory chain; TAS:ProtInc.
 GO:0005750; C:mitochondrial respiratory chain complex III; IEA:InterPro.
 GO:0009060; P:aerobic respiration; TAS:ProtInc.
 GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IEA:InterPro.
 GO:0006119; P:oxidative phosphorylation; TAS:ProtInc.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR003197; QCR7. 

Pfam

 PF02271; UCR_14kD 

SMART

  

PROSITE

  

PRINTS