CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021560
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongator complex protein 3 
Protein Synonyms/Alias
 hELP3 
Gene Name
 ELP3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20IEAHEQGKDIDLNKVubiquitination[1]
34VKTKTAAKYGLSAQPubiquitination[1]
192NNIYEAVKYSERSLTubiquitination[1]
319TGLYELWKSGRYKSYubiquitination[1]
324LWKSGRYKSYSPSDLubiquitination[1]
503REEHGSGKIAVISGVubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration. 
Sequence Annotation
 DOMAIN 396 547 N-acetyltransferase.
 METAL 99 99 Iron-sulfur (4Fe-4S-S-AdoMet) (By
 METAL 109 109 Iron-sulfur (4Fe-4S-S-AdoMet) (By
 METAL 112 112 Iron-sulfur (4Fe-4S-S-AdoMet) (By
 MOD_RES 202 202 Phosphotyrosine.  
Keyword
 Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 547 AA 
Protein Sequence
MMLTIGDVIK QLIEAHEQGK DIDLNKVKTK TAAKYGLSAQ PRLVDIIAAV PPQYRKVLMP 60
KLKAKPIRTA SGIAVVAVMC KPHRCPHISF TGNICVYCPG GPDSDFEYST QSYTGYEPTS 120
MRAIRARYDP FLQTRHRIEQ LKQLGHSVDK VEFIVMGGTF MALPEEYRDY FIRNLHDALS 180
GHTSNNIYEA VKYSERSLTK CIGITIETRP DYCMKRHLSD MLTYGCTRLE IGVQSVYEDV 240
ARDTNRGHTV KAVCESFHLA KDSGFKVVAH MMPDLPNVGL ERDIEQFTEF FENPAFRPDG 300
LKLYPTLVIR GTGLYELWKS GRYKSYSPSD LVELVARILA LVPPWTRVYR VQRDIPMPLV 360
SSGVEHGNLR ELALARMKDL GIQCRDVRTR EVGIQEIHHK VRPYQVELVR RDYVANGGWE 420
TFLSYEDPDQ DILIGLLRLR KCSEETFRFE LGGGVSIVRE LHVYGSVVPV SSRDPTKFQH 480
QGFGMLLMEE AERIAREEHG SGKIAVISGV GTRNYYRKIG YRLQGPYMVK MLK 533 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IDA:HGNC.
 GO:0033588; C:Elongator holoenzyme complex; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HGNC.
 GO:0008023; C:transcription elongation factor complex; IDA:UniProtKB.
 GO:0004402; F:histone acetyltransferase activity; IEA:EC.
 GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008607; F:phosphorylase kinase regulator activity; IDA:UniProtKB.
 GO:0016573; P:histone acetylation; IEA:GOC.
 GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:HGNC. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR006638; Elp3/MiaB/NifB.
 IPR000182; GNAT_dom.
 IPR005910; Hist_AcTrfase_ELP3.
 IPR007197; rSAM.
 IPR023404; rSAM_horseshoe. 
Pfam
 PF00583; Acetyltransf_1
 PF04055; Radical_SAM 
SMART
 SM00729; Elp3 
PROSITE
 PS51186; GNAT 
PRINTS