CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005093
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium/calmodulin-dependent protein kinase II 
Protein Synonyms/Alias
  
Gene Name
 CMK2 
Gene Synonyms/Alias
 YOL016C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
173NVVHRDLKPENVLYVubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Important in cellular regulation. 
Sequence Annotation
 DOMAIN 47 309 Protein kinase.
 NP_BIND 53 61 ATP (By similarity).
 REGION 323 334 Calmodulin-binding (By similarity).
 ACT_SITE 171 171 Proton acceptor (By similarity).
 BINDING 76 76 ATP (By similarity).
 MOD_RES 316 316 Phosphothreonine; by autocatalysis (By
 MOD_RES 353 353 Phosphotyrosine.
 MOD_RES 354 354 Phosphoserine.
 MOD_RES 367 367 Phosphoserine.
 MOD_RES 371 371 Phosphoserine.
 MOD_RES 387 387 Phosphoserine; by autocatalysis (By
 MOD_RES 443 443 Phosphoserine.  
Keyword
 ATP-binding; Calmodulin-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 447 AA 
Protein Sequence
MPKESEVINS EFHVDVQDPE RLNGHPVAKF INKLSGQPES YVNRTNYIFG RTLGAGSFGV 60
VRQARKLSTN EDVAIKILLK KALQGNNVQL QMLYEELSIL QKLSHPNIVS FKDWFESKDK 120
FYIVTQLATG GELFDRILSR GKFTEVDAVE IIVQILGAVE YMHSKNVVHR DLKPENVLYV 180
DKSENSPLVI ADFGIAKQLK GEEDLIYKAA GSLGYVAPEV LTQDGHGKPC DIWSIGVITY 240
TLLCGYSPFI AESVEGFMEE CTASRYPVTF HMPYWDNISI DVKRFILKAL RLNPADRPTA 300
TELLDDPWIT SKRVETSNIL PDVKKGFSLR KKLRDAIEIV KLNNRIKRLR NMYSLGDDGD 360
NDIEENSLNE SLLDGVTHSL DDLRLQSQKK GGELTEEQMK LKSALTKDAF VQIVKAATKN 420
KHKVLAGEEE DDSKKTLHDD RESKSED 447 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004683; F:calmodulin-dependent protein kinase activity; IDA:SGD.
 GO:0007165; P:signal transduction; NAS:SGD. 
Interpro
 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS