UniProt Accession

 E9PWC8_MOUSE; E9PWC8 

Genbank Protein ID

 AC144543; AC158526 

Genbank Nucleotide ID

  

Protein Name

 Poly(A) polymerase alpha 

Protein Synonyms/Alias

  

Gene Name

 Papola 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
360	LSKAEWSKLFEAPNF	ubiquitination	[1]
635	PSGNTATKVPNPIVG	acetylation	[2]
644	PNPIVGVKRTSSPNK	acetylation	[2, 3, 4]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 693 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0004652; F:polynucleotide adenylyltransferase activity; IDA:MGI.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006378; P:mRNA polyadenylation; IBA:RefGenome.
 GO:0000398; P:mRNA splicing, via spliceosome; IBA:RefGenome.
 GO:0006369; P:termination of RNA polymerase II transcription; IBA:RefGenome. 

Interpro

 IPR002934; Nucleotidyltransferase.
 IPR011068; NuclTrfase_I_C.
 IPR007012; PolA_pol_cen_dom.
 IPR007010; PolA_pol_RNA-bd_dom.
 IPR014492; PolyA_polymerase. 

Pfam

 PF01909; NTP_transf_2
 PF04928; PAP_central
 PF04926; PAP_RNA-bind 

SMART

  

PROSITE

  

PRINTS