CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016444
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleotide-binding oligomerization domain-containing protein 1 
Protein Synonyms/Alias
 Caspase recruitment domain-containing protein 4 
Gene Name
 Nod1 
Gene Synonyms/Alias
 Card4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
937CLNGNLIKPEEAKVFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Recruits NLRP10 to the cell membrane following bacterial infection (By similarity). 
Sequence Annotation
 DOMAIN 15 107 CARD.
 DOMAIN 196 531 NACHT.
 REPEAT 702 725 LRR 1.
 REPEAT 727 750 LRR 2.
 REPEAT 755 778 LRR 3.
 REPEAT 783 806 LRR 4.
 REPEAT 839 862 LRR 5.
 REPEAT 867 890 LRR 6.
 REPEAT 895 918 LRR 7.
 REPEAT 923 946 LRR 8.
 NP_BIND 202 209 ATP (Potential).  
Keyword
 Apoptosis; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Immunity; Innate immunity; Leucine-rich repeat; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 953 AA 
Protein Sequence
MEEHGHHEME GTPLGCHSHI KLLKINREHL VTNIRNTQCL VDNLLENGYF SAEDAEIVCA 60
CPTKPDKVRK ILDLVQSKGE EVSEFFLYVL QQLEDAYVDL RLWLSEIGFS PSQLIRTKTI 120
VNTDPVSRYT QQLRHQLGRD SKFMLCYAQK EDLLLEETYM DTLMELVGFN NENLGSLGGL 180
DCLLDHSTGV LNEHGETVFV FGDAGVGKSM LLQRLQSLWA SGRLTSTAKF FFHFRCRMFS 240
CFKESDMLSL QDLLFKHFCY PEQDPEEVFS FLLRFPHTAL FTFDGLDELH SDFDLSRVPD 300
SCCPWEPAHP LVLLANLLSG RLLKGAGKLL TARTGVEVPR QLLRKKVLLR GFSPSHLRAY 360
ARRMFPERTA QEHLLQQLDA NPNLCSLCGV PLFCWIIFRC FQHFQTVFEG SSSQLPDCAV 420
TLTDVFLLVT EVHLNRPQPS SLVQRNTRSP AETLRAGWRT LHALGEVAHR GTDKSLFVFG 480
QEEVQASKLQ EGDLQLGFLR ALPDVGPEQG QSYEFFHLTL QAFFTAFFLV ADDKVSTREL 540
LRFFREWTSP GEATSSSCHS SFFSFQCLGG RSRLGPDPFR NKDHFQFTNL FLCGLLAKAR 600
QKLLRQLVPK AILRRKRKAL WAHLFASLRS YLKSLPRVQS GGFNQVHAMP TFLWMLRCIY 660
ETQSQKVGRL AARGISADYL KLAFCNACSA DCSALSFVLH HFHRQLALDL DNNNLNDYGV 720
QELQPCFSRL TVIRLSVNQI TDTGVKVLCE ELTKYKIVTF LGLYNNQITD IGARYVAQIL 780
DECRGLKHLK LGKNRITSEG GKCVALAVKN STSIVDVGMW GNQIGDEGAK AFAEALKDHP 840
SLTTLSLAFN GISPEGGKSL AQALKQNTTL TVIWLTKNEL NDESAECFAE MLRVNQTLRH 900
LWLIQNRITA KGTAQLARAL QKNTAITEIC LNGNLIKPEE AKVFENEKRI ICF 953 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
 GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI.
 GO:0016045; P:detection of bacterium; ISS:HGNC.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0042228; P:interleukin-8 biosynthetic process; ISS:HGNC.
 GO:0035556; P:intracellular signal transduction; ISS:HGNC.
 GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IMP:BHF-UCL.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:MGI.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IDA:MGI.
 GO:0032755; P:positive regulation of interleukin-6 production; IMP:MGI.
 GO:0046330; P:positive regulation of JNK cascade; IDA:MGI.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
 GO:0032760; P:positive regulation of tumor necrosis factor production; IMP:MGI. 
Interpro
 IPR001315; CARD.
 IPR011029; DEATH-like_dom.
 IPR007111; NACHT_NTPase. 
Pfam
 PF00619; CARD 
SMART
  
PROSITE
 PS50209; CARD
 PS50837; NACHT 
PRINTS