| Tag | Content |
|---|
| CPLM ID | CPLM-006661 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | HTH-type transcriptional regulator TreR |
Protein Synonyms/Alias | Trehalose operon repressor |
Gene Name | treR |
Gene Synonyms/Alias | b4241; JW4200 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 192 | HSDVTTGKRRHEAYL | acetylation | [1] | | 203 | EAYLAFCKAHKLHPV | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Repressor of the treBC operon. Binds trehalose 6- phosphate as an inducer. |
Sequence Annotation | DOMAIN 5 59 HTH lacI-type.
DNA_BIND 7 26 H-T-H motif (Potential). |
Keyword | 3D-structure; Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 315 AA |
Protein Sequence | MQNRLTIKDI ARLSGVGKST VSRVLNNESG VSQLTRERVE AVMNQHGFSP SRSARAMRGQ 60
SDKVVAIIVT RLDSLSENLA VQTMLPAFYE QGYDPIMMES QFSPQLVAEH LGVLKRRNID 120
GVVLFGFTGI TEEMLAHWQS SLVLLARDAK GFASVCYDDE GAIKILMQRL YDQGHRNISY 180
LGVPHSDVTT GKRRHEAYLA FCKAHKLHPV AALPGLAMKQ GYENVAKVIT PETTALLCAT 240
DTLALGASKY LQEQRIDTLQ LASVGNTPLM KFLHPEIVTV DPGYAEAGRQ AACQLIAQVT 300
GRSEPQQIII PATLS 315 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc. GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:EcoCyc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0005991; P:trehalose metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |