CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010931
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tumor necrosis factor receptor superfamily member 17 
Protein Synonyms/Alias
 B-cell maturation protein; CD269 
Gene Name
 TNFRSF17 
Gene Synonyms/Alias
 BCM; BCMA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106MANIDLEKSRTGDEIubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. 
Sequence Annotation
 REPEAT 7 41 TNFR-Cys.
 DISULFID 8 21
 DISULFID 24 37
 DISULFID 28 41  
Keyword
 3D-structure; Adaptive immunity; Cell membrane; Chromosomal rearrangement; Complete proteome; Disulfide bond; Immunity; Membrane; Polymorphism; Proto-oncogene; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 184 AA 
Protein Sequence
MLQMAGQCSQ NEYFDSLLHA CIPCQLRCSS NTPPLTCQRY CNASVTNSVK GTNAILWTCL 60
GLSLIISLAV FVLMFLLRKI NSEPLKDEFK NTGSGLLGMA NIDLEKSRTG DEIILPRGLE 120
YTVEECTCED CIKSKPKVDS DHCFPLPAME EGATILVTTK TNDYCKSLPA ALSATEIEKS 180
ISAR 184 
Gene Ontology
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR015337; BCMA_Tall-1-bd.
 IPR022320; TNFR_17. 
Pfam
 PF09257; BCMA-Tall_bind 
SMART
  
PROSITE
 PS00652; TNFR_NGFR_1
 PS50050; TNFR_NGFR_2 
PRINTS
 PR01967; TNFACTORR17.