CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000486
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 3-hydroxyacyl-CoA dehydrogenase type-2 
Protein Synonyms/Alias
 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Scully protein; Type II HADH 
Gene Name
 scu 
Gene Synonyms/Alias
 CG7113 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
46SKGNEVAKELGDKVVacetylation[1]
99VKTFNFNKNVAHRLEacetylation[1]
213KVRTFLAKSIPFPQRacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 May function in mitochondrial tRNA maturation (By similarity). May play a role in germline formation. 
Sequence Annotation
 NP_BIND 6 31 NAD (By similarity).
 ACT_SITE 162 162 Proton acceptor (By similarity).
 BINDING 149 149 Substrate (By similarity).  
Keyword
 Complete proteome; Mitochondrion; NAD; Oxidoreductase; Reference proteome; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 255 AA 
Protein Sequence
MIKNAVSLVT GGASGLGRAT AERLAKQGAS VILADLPSSK GNEVAKELGD KVVFVPVDVT 60
SEKDVSAALQ TAKDKFGRLD LTVNCAGTAT AVKTFNFNKN VAHRLEDFQR VININTVGTF 120
NVIRLSAGLM GANEPNQDGQ RGVIVNTASV AAFDGQIGQA AYSASKAAVV GMTLPIARDL 180
STQGIRICTI APGLFNTPML AALPEKVRTF LAKSIPFPQR LGEPSEYAHL VQAIYENPLL 240
NGEVIRIDGA LRMMP 255 
Gene Ontology
 GO:0005829; C:cytosol; NAS:FlyBase.
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0047015; F:3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; IEA:EC.
 GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:EC.
 GO:0047022; F:7-beta-hydroxysteroid dehydrogenase (NADP+) activity; IDA:FlyBase.
 GO:0018454; F:acetoacetyl-CoA reductase activity; IDA:FlyBase.
 GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IDA:FlyBase.
 GO:0050327; F:testosterone 17-beta-dehydrogenase (NAD+) activity; IDA:FlyBase.
 GO:0047035; F:testosterone dehydrogenase (NAD+) activity; IDA:FlyBase.
 GO:0006637; P:acyl-CoA metabolic process; IDA:FlyBase.
 GO:0008209; P:androgen metabolic process; IDA:FlyBase.
 GO:0008205; P:ecdysone metabolic process; IDA:FlyBase.
 GO:0008210; P:estrogen metabolic process; IDA:FlyBase.
 GO:0006631; P:fatty acid metabolic process; IDA:FlyBase.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.