UniProt Accession

 TP53B_HUMAN; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4 

Genbank Protein ID

 AF078776; AB210025; BX537418; AY904026; BC112161; U09477 

Genbank Nucleotide ID

 AAC62018.1; BAE06107.1; CAD97660.1; AAW69392.1; AAI12162.1; AAA21596.1 

Protein Name

 Tumor suppressor p53-binding protein 1 

Protein Synonyms/Alias

 53BP1; p53-binding protein 1; p53BP1 

Gene Name

 TP53BP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
532	SEYSQSPKMESLSSH	ubiquitination	[1]
878	DSKMANAKQLSSDAE	ubiquitination	[2]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation. 

Sequence Annotation

 DOMAIN 1724 1848 BRCT 1.
 DOMAIN 1864 1964 BRCT 2.
 REGION 1483 1604 Tudor-like.
 REGION 1495 1523 Interaction with dimethylated histone H4.
 MOTIF 1396 1403 GAR.
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 124 124 Phosphoserine.
 MOD_RES 166 166 Phosphoserine.
 MOD_RES 176 176 Phosphoserine (Probable).
 MOD_RES 178 178 Phosphoserine (Probable).
 MOD_RES 222 222 Phosphoserine.
 MOD_RES 265 265 Phosphoserine.
 MOD_RES 294 294 Phosphoserine.
 MOD_RES 302 302 Phosphothreonine.
 MOD_RES 366 366 Phosphoserine.
 MOD_RES 380 380 Phosphoserine.
 MOD_RES 395 395 Phosphoserine.
 MOD_RES 398 398 Phosphoserine.
 MOD_RES 452 452 Phosphoserine.
 MOD_RES 500 500 Phosphoserine.
 MOD_RES 523 523 Phosphoserine.
 MOD_RES 525 525 Phosphoserine.
 MOD_RES 543 543 Phosphothreonine.
 MOD_RES 548 548 Phosphothreonine.
 MOD_RES 552 552 Phosphoserine.
 MOD_RES 566 566 Phosphoserine.
 MOD_RES 580 580 Phosphoserine.
 MOD_RES 635 635 Phosphoserine.
 MOD_RES 639 639 Phosphoserine.
 MOD_RES 640 640 Phosphoserine.
 MOD_RES 809 809 Phosphoserine.
 MOD_RES 831 831 Phosphoserine.
 MOD_RES 834 834 Phosphoserine.
 MOD_RES 855 855 Phosphothreonine.
 MOD_RES 922 922 Phosphothreonine.
 MOD_RES 970 970 Phosphoserine.
 MOD_RES 975 975 Phosphoserine.
 MOD_RES 1028 1028 Phosphoserine.
 MOD_RES 1068 1068 Phosphoserine.
 MOD_RES 1094 1094 Phosphoserine.
 MOD_RES 1101 1101 Phosphoserine.
 MOD_RES 1114 1114 Phosphoserine.
 MOD_RES 1214 1214 Phosphothreonine.
 MOD_RES 1216 1216 Phosphoserine.
 MOD_RES 1219 1219 Phosphoserine.
 MOD_RES 1362 1362 Phosphoserine.
 MOD_RES 1368 1368 Phosphoserine.
 MOD_RES 1372 1372 Phosphothreonine.
 MOD_RES 1426 1426 Phosphoserine.
 MOD_RES 1430 1430 Phosphoserine.
 MOD_RES 1460 1460 Phosphoserine.
 MOD_RES 1462 1462 Phosphoserine.
 MOD_RES 1474 1474 Phosphoserine.
 MOD_RES 1609 1609 Phosphothreonine.
 MOD_RES 1618 1618 Phosphoserine.
 MOD_RES 1678 1678 Phosphoserine.
 MOD_RES 1701 1701 Phosphoserine.
 MOD_RES 1759 1759 Phosphoserine.  

Keyword

 3D-structure; Activator; Alternative splicing; Centromere; Chromosomal rearrangement; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Kinetochore; Methylation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1972 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:ProtInc.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005657; C:replication fork; IEA:Compara.
 GO:0003684; F:damaged DNA binding; IEA:Compara.
 GO:0035064; F:methylated histone residue binding; IDA:UniProtKB.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IMP:BHF-UCL.
 GO:0042162; F:telomeric DNA binding; IEA:Compara.
 GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IC:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL. 

Interpro

 IPR015125; 53-BP1_Tudor.
 IPR001357; BRCT_dom.
 IPR014722; Rib_L2_dom2. 

Pfam

 PF09038; 53-BP1_Tudor 

SMART

 SM00292; BRCT 

PROSITE

 PS50172; BRCT 

PRINTS