CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040880
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Proteasome activator complex subunit 4 
Protein Synonyms/Alias
  
Gene Name
 PSME4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60HEFDSRWKSFNLVKKubiquitination[1, 2]
226LFDDLAEKIHRQYETubiquitination[2, 3]
490PRRFCLFKGIFRNFDubiquitination[4]
763DNSYDELKRDAKLCLubiquitination[2, 3, 5]
902IPSAELVKRHAGVLGubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 987 AA 
Protein Sequence
MGENLAKKIM FFLLTIKLIL NHILDNSEDD TKSLFLIIKI IGDLLQFQGS HKHEFDSRWK 60
SFNLVKKSME NRLHGKKQHI RALLIDRVML QHELRTLTVE GCEYKKIHQD MIRDLLRLST 120
SSYSQVRNKA QQTFFAALGA YNFCCRDIIP LVLEFLRPDR QGVTQQQFKG ALYCLLGNHS 180
GVCLANLHDW DCIVQTWPAI VSSGLSQAMS LEKPSIVRLF DDLAEKIHRQ YETIGLDFTI 240
PKSCVEIAEL LQQSKNPSIN QILLSPEKIK EGIKRQQEKN ADALRNYENL VDTLLDGVEQ 300
RNLPWKFEHI GIGLLSLLLR DDRVLPLRAI RFFVENLNHD AIVVRKMAIS AVAGILKQLK 360
RTHKKLTINP CEISGCPKPT QIIAGDRPDN HWLHYDSKTI PRTKKEWESS CFVEKTHWGY 420
YTWPKNMVVY AGVEEQPKLG RSREDMTEAE QIIFDHFSDP KFVEQLITFL SLEDRKGKDK 480
FNPRRFCLFK GIFRNFDDAF LPVLKPHLEH LVADSHESTQ RCVAEIIAGL IRGSKHWTFE 540
KVEKLWELLC PLLRTALSNI TVETYNDWGA CIATSCESRD PRKLHWLFEL LLESPLSGEG 600
GSFVDACRLY VLQGGLAQQE WRVPELLHRL LKYLEPKLTQ VYKNVRERIG SVLTYIFMID 660
VSLPNTTPTI SPHVPEFTAR ILEKLKPLMD VDEEIQNHVM EENGIGEEDE RTQGIKLLKT 720
ILKWLMASAG RSFSTAVTEQ LQLLPLFFKI APVENDNSYD ELKRDAKLCL SLMSQGLLYP 780
HQVPLVLQVL KQTARSSSWH ARYTVLTYLQ TMVFYNLFIF LNNEDAVKDI RWLVISLLED 840
EQLEVREMAA TTLSGLLQCN FLTMDSPMQI HFEQLCKTKL PKKRKRDPGS VGDTIPSAEL 900
VKRHAGVLGL GACVLSSPYD VPTWMPQLLM NLSAHLNDPQ PIEMTVKKTL SNFRRTHHDN 960
WQEHKQQFTD DQLLVLTDLL VSPCYYA 987 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR021843; DUF3437. 
Pfam
 PF11919; DUF3437 
SMART
  
PROSITE
  
PRINTS