CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016912
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Abnormal spindle-like microcephaly-associated protein homolog 
Protein Synonyms/Alias
 Calmodulin-binding protein Sha1; Calmodulin-binding protein 1; Spindle and hydroxyurea checkpoint abnormal protein 
Gene Name
 Aspm 
Gene Synonyms/Alias
 Calmbp1; Sha1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1741TARQRYLKMCKAALVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis. 
Sequence Annotation
 DOMAIN 888 1024 CH 1.
 DOMAIN 1078 1189 CH 2.
 DOMAIN 1234 1263 IQ 1.
 DOMAIN 1315 1346 IQ 2.
 DOMAIN 1410 1439 IQ 3.
 DOMAIN 1504 1535 IQ 4.
 DOMAIN 1550 1579 IQ 5.
 DOMAIN 1600 1629 IQ 6.
 DOMAIN 1623 1652 IQ 7.
 DOMAIN 1696 1725 IQ 8.
 DOMAIN 1719 1750 IQ 9.
 DOMAIN 1769 1798 IQ 10.
 DOMAIN 1792 1821 IQ 11.
 DOMAIN 1842 1871 IQ 12.
 DOMAIN 1865 1896 IQ 13.
 DOMAIN 1915 1946 IQ 14.
 DOMAIN 1938 1967 IQ 15.
 DOMAIN 1988 2017 IQ 16.
 DOMAIN 2011 2042 IQ 17.
 DOMAIN 2061 2092 IQ 18.
 DOMAIN 2134 2165 IQ 19.
 DOMAIN 2157 2188 IQ 20.
 DOMAIN 2207 2238 IQ 21.
 DOMAIN 2230 2261 IQ 22.
 DOMAIN 2279 2310 IQ 23.
 DOMAIN 2302 2333 IQ 24.
 DOMAIN 2343 2374 IQ 25.
 DOMAIN 2366 2397 IQ 26.
 DOMAIN 2416 2447 IQ 27.
 DOMAIN 2491 2522 IQ 28.
 DOMAIN 2602 2633 IQ 29.
 DOMAIN 2674 2705 IQ 30.
 DOMAIN 2724 2755 IQ 31.
 DOMAIN 2849 2880 IQ 32.
 MOD_RES 348 348 Phosphoserine (By similarity).
 MOD_RES 373 373 Phosphoserine (By similarity).
 MOD_RES 1071 1071 Phosphoserine (By similarity).  
Keyword
 Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3122 AA 
Protein Sequence
MATMQAASCP EERGRRARPD PEAGDPSPPV LLLSHFCGVP FLCFGDVRVG TSRTRSLVLH 60
NPHEEPLQVE LSLLRAAGQG FSVAPNRCEL KPKEKLTISV TWTPLREGGV REIVTFLVND 120
FLKHQAILLG NAEEPKKKKR SLWNTSKKIP ASSKHTKRTS KNQHFNESFT ISQKDRIRSP 180
LQPCENLAMS ECSSPTENKV PTPSISPIRE CQSETCLPLF LRESTAYSSL HESENTQNLK 240
VQDASISQTF DFNEEVANET FINPISVCHQ SEGDRKLTLA PNCSSPLNST QTQIHFLSPD 300
SFVNNRYTSD NDLKSMKNVL SDTFRKDPAE SVCLESQTVH EVCQTILSPD SFLNDNYGLK 360
KGLNFKSVNP VLSPTQFVKD SMGHVGQQTG KSNEASQDWR INEGLAYTPE CQHAQTPSSR 420
SEKQNPVEVK PHTYDFTKQK PKISEFQDAF CHQSKQPHKR RPILSATVTK RKPTNAREKL 480
PEINKPDAKR CLEGLVGERG KEVGSLREKG FHSSLPVVEP GVSKALSYRD EVTPATVVVA 540
RKRKSHGTVG DANGKVAAEE WMDMCEVKRI HFSPLESTPS TVARTTKKEG HTSKRISSLE 600
RSGLKKKMDS SILKTPLSKT KKKRRSIVAV AQSHLTFIKP LKAAIPRHPM PFAAKNMFYD 660
ERWKEKQEQG FTWWLNYILT PDDFTVKTNV SKVNAASLVL GAESQHKISV PKAPTKEEVS 720
LRAYTASCRL NRLRRTACSL FTSEKMVKAI KKVEIEIEVG RLLVRKDRHL WKDIGQRQKV 780
LNWLLSYNPL WLRIGLETVF GELIPLADNS DVTGLAMFIL NRLLWNPDIA AEYRHPTVPL 840
LFRDGHEAAL SKFTLKKLLL LICFLDHAKI SRLIDHDPCL FCKDAEFKAS KELLLAFSRD 900
FLSGEGDLSR HLSFLGLPVS HVQTPLDEFD FAVTNLAVDL QCGVRLVRTV ELLTQNWNLS 960
DKLRIPAISR VQKMHNVDLV LQVLKSRGVP LTDEHGSAIS SKDVVDRHRE KTLGLLWKIA 1020
LAFQVDISLN LDQLKEEIDF LKHTHSIKRA MSALTCPSQA ITNKQRDKRI SGNFERYGDS 1080
VQLLMDWVNA VCAFYNKKVE NFTVSFSDGR ILCYLIHHYH PCYVPFDAIC QRTSQSVACA 1140
QTGSVVLNSS SESEGGCLDL SLEALDHEST PEMYKELLEN EKKNFHLVRS AARDLGGIPA 1200
MIHHSDMSNT IPDEKVVITY LSFLCARLLD LRKEIRAARL IQTTWRKYKL KRDLKHHQER 1260
DKAARVIQSV VLNFLSRRRL QKNVSAALVI QKCWRRVSAQ RKLRMLKNEK LAKLQNKSAV 1320
LIQAYWRRYS TRKRFLRLKH YSVILQSRIR MKIALTSYKR YLWATVTIQR HWRAYLSRKR 1380
DQQIFRKLKS SSLVIQFMFR RWKRRKLQLQ TKAAVTLQRA FREWHLRKQI RERSAVVIQS 1440
WYRMHRELQK YIYIRSCVIV IQRRVRCFQA QKLYKRRKDA ILTLQKHYRA RQKGKLAHAD 1500
YLQKRAATIR LQAAFRGMKA RHSYRLQIGA ACVLQSYWRM RQERVRFLNL KKMVIKLQAH 1560
IRKYQQLQKY KKIKKAAITI QTHFRASISA RRVLASYQKT RSSVIVLQSA CRGMQARKAF 1620
RHALASVIKI QSYYRAYICR KTFQNFKNAT IKLQSIVKMK QSRKQYLQIR AAALFIQRWY 1680
RSQKLASQKR KEYIQVRESC IKLQSHFRGC LVRKQLRLQC KAAISLQSYF RMRTARQRYL 1740
KMCKAALVIQ SFYCAYRAQI SQRKNFLQVK RAAICLQAAY RGCKVRRQIK QQSTAAVTIQ 1800
RVFRGHSQRM KYQTMLQSAV KIQRWYRAQK VAYDMRIQFL KTREAVVCLQ SAYRGWQVRQ 1860
QLRRQHEAAV KIQSTFRMAV AQQQYKLLRA AAAVIQQHVR ARAAGKRQHL AYIQLRHAAL 1920
VFQAAWKGKM LRRQIARQHQ CAALIQSYYR MHIQRRKWSI MKTAALQIQL CYRAYKVGKE 1980
QRHLYLKTKA AVVTLQSAYR GMKVRKRVAE CHKAAVTIQS KFRAYRTQKK YTTYRTSAIV 2040
IQRWYRNIKI TTQQHQEYLN LRRAAVQVQA AYRGIRVRRR IQHMHMAATL IEAMFKMRQS 2100
RVRYLKMRTA ALIIQVRYRA YYLGKIQHEK YLRTLKAIKT LQAGVRGARV RRTVRKMHFA 2160
ATLIQSHFRG HRQQTYFHRL RKAATMVQQR YRAVKEGSAE FQRYSRLRRS VLLIQAAFRG 2220
LRTRRHLKAM HLAATLIQRR FRTFAMRRKF LSLRKTAIWI QRQYRARLYA KYSRQQLLLE 2280
KAVIKIQSSY RGWVVRKRVQ KMHRAATVIQ ATFRMHGAYM RYQHLKRASV VIQVHTAAEL 2340
QRQKHAAVIL QAAVRGMKTR SHLKTMHSSA TLIQSQFRAF IVRRRFIALR KAAIFVQRKF 2400
RATLYAKHKL HQFLQLRKAA ITIQSSYRRL MVQKKLQEMH RAAALIQATF RMHRTYVAFH 2460
IWKCASIRIQ QCYRTYRTIK LQKEKLIREE QHSAAVLIQS TYRMYRQRCF YQQRRWAAKV 2520
IQKTYRANKR RQDLLYVCKE ETPLLQMHFQ GLNTAKQGRQ QHGAAMITQK HFRAFKARRL 2580
MEAERGFQAG CRKYKAKKYL SKVEAACRIQ AWYRRWRAHK KYLTLLKAVN IIEGYLSAQL 2640
ARRRFLKMRA AAIIIQRKWR ATLSVRGARE NLKRHRAACV IQAHFRGYQA RQSFLQQRSA 2700
VLIIQRHVRA MVAAKQERIK YIKLKKSTVV VQALVRGWLV RKRVSEQKAK TRLFHFTAAA 2760
YCHMCALKIQ RAYRLHVTLR NAKKHMDSVI FIQRWFRKRL QRKRFIEQYH KILSTRREAH 2820
ACWLQQDRAA SVIQKAVRRF LLCRRQEKIT SCATRIQALW RGYSWRKKND HTEIKAIRRS 2880
LRAVSTTVEE ENKLYRRTER ALHHLLTYKH LSAILDALKH LEVVTRLSPL CCENMAESGA 2940
VSTIFVVIRS CNRSVPCMEV VGYAVQVLLN VAKYDKTIAA VYEAENCVDT LLELLQVYRE 3000
KPGDRVAEKS ASIFTRTCCL LAVLLKTEQC AFDAQSRSKV TDRIYRLYKF TVPKHKVNTQ 3060
GLFDKQKQNS CVGFPCIPER TMKTRLVSRL KPQWVLRRDN VEEITNSLQA IQLVMDTLGI 3120
SY 3122 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000922; C:spindle pole; IDA:MGI.
 GO:0048589; P:developmental growth; IMP:MGI.
 GO:0021873; P:forebrain neuroblast division; IMP:MGI.
 GO:0051661; P:maintenance of centrosome location; IMP:MGI.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0045769; P:negative regulation of asymmetric cell division; IMP:MGI.
 GO:0045665; P:negative regulation of neuron differentiation; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0048477; P:oogenesis; IMP:MGI.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IGI:MGI.
 GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI.
 GO:0007283; P:spermatogenesis; IMP:MGI. 
Interpro
 IPR022613; CAMSAP_CH.
 IPR001715; CH-domain.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF11971; CAMSAP_CH
 PF00612; IQ 
SMART
 SM00033; CH
 SM00015; IQ 
PROSITE
 PS50021; CH
 PS50096; IQ 
PRINTS