UniProt Accession

 GPX41_MOUSE; O70325; O35560; Q9JK35 

Genbank Protein ID

 D87896; AJ012104; AF045768; AF045769; AF044056; AB030643; AB030643; AB030728; AK006441 

Genbank Nucleotide ID

 BAA22780.1; CAB42657.2; AAC15832.1; AAC15833.1; AAC14560.1; BAC06507.1; BAC06508.1; BAC06511.1; BAC55251.1 

Protein Name

 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial 

Protein Synonyms/Alias

 PHGPx; Glutathione peroxidase 4; GPx-4; GSHPx-4 

Gene Name

 Gpx4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
58	GHMVCLDKYRGFVCI	acetylation	[1]
117	PGSNQEIKEFAAGYN	ubiquitination	[2]
126	FAAGYNVKFDMYSKI	ubiquitination	[2]
162	GMLGNAIKWNFTKFL	ubiquitination	[2]
191	EEPQVIEKDLPCYL*	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Protects cells against membrane lipid peroxidation and cell death. Isoform mitochondrial is required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. 

Sequence Annotation

 ACT_SITE 73 73  

Keyword

 Alternative initiation; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Mitochondrion; Oxidoreductase; Peroxidase; Reference proteome; Selenocysteine; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 197 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0004602; F:glutathione peroxidase activity; IDA:MGI.
 GO:0047066; F:phospholipid-hydroperoxide glutathione peroxidase activity; IEA:EC.
 GO:0006325; P:chromatin organization; IDA:MGI.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006979; P:response to oxidative stress; IEA:InterPro.
 GO:0007283; P:spermatogenesis; IDA:MGI. 

Interpro

 IPR000889; Glutathione_peroxidase.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00255; GSHPx 

SMART

  

PROSITE

 PS00460; GLUTATHIONE_PEROXID_1
 PS00763; GLUTATHIONE_PEROXID_2
 PS51355; GLUTATHIONE_PEROXID_3 

PRINTS

 PR01011; GLUTPROXDASE.