CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021255
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oxysterol-binding protein-related protein 5 
Protein Synonyms/Alias
 ORP-5; OSBP-related protein 5; Oxysterol-binding protein homolog 1 
Gene Name
 OSBPL5 
Gene Synonyms/Alias
 KIAA1534; OBPH1; ORP5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
205VWAVKGPKGESVGSIubiquitination[1]
402EPRSFLNKLSDYYYHubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. 
Sequence Annotation
 DOMAIN 126 243 PH.
 MOD_RES 747 747 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Endoplasmic reticulum; Lipid transport; Lipid-binding; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 879 AA 
Protein Sequence
MKEEAFLRRR FSLCPPSSTP QKVDPRKLTR NLLLSGDNEL YPLSPGKDME PNGPSLPRDE 60
GPPTPSSATK VPPAEYRLCN GSDKECVSPT ARVTKKETLK AQKENYRQEK KRATRQLLSA 120
LTDPSVVIMA DSLKIRGTLK SWTKLWCVLK PGVLLIYKTP KVGQWVGTVL LHCCELIERP 180
SKKDGFCFKL FHPLDQSVWA VKGPKGESVG SITQPLPSSY LIFRAASESD GRCWLDALEL 240
ALRCSSLLRL GTCKPGRDGE PGTSPDASPS SLCGLPASAT VHPDQDLFPL NGSSLENDAF 300
SDKSERENPE ESDTETQDHS RKTESGSDQS ETPGAPVRRG TTYVEQVQEE LGELGEASQV 360
ETVSEENKSL MWTLLKQLRP GMDLSRVVLP TFVLEPRSFL NKLSDYYYHA DLLSRAAVEE 420
DAYSRMKLVL RWYLSGFYKK PKGIKKPYNP ILGETFRCCW FHPQTDSRTF YIAEQVSHHP 480
PVSAFHVSNR KDGFCISGSI TAKSRFYGNS LSALLDGKAT LTFLNRAEDY TLTMPYAHCK 540
GILYGTMTLE LGGKVTIECA KNNFQAQLEF KLKPFFGGST SINQISGKIT SGEEVLASLS 600
GHWDRDVFIK EEGSGSSALF WTPSGEVRRQ RLRQHTVPLE EQTELESERL WQHVTRAISK 660
GDQHRATQEK FALEEAQRQR ARERQESLMP WKPQLFHLDP ITQEWHYRYE DHSPWDPLKD 720
IAQFEQDGIL RTLQQEAVAR QTTFLGSPGP RHERSGPDQR LRKASDQPSG HSQATESSGS 780
TPESCPELSD EEQDGDFVPG GESPCPRCRK EARRLQALHE AILSIREAQQ ELHRHLSAML 840
SSTARAAQAP TPGLLQSPRS WFLLCVFLAC QLFINHILK 879 
Gene Ontology
 GO:0005829; C:cytosol; NAS:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015485; F:cholesterol binding; IDA:BHF-UCL.
 GO:0008142; F:oxysterol binding; NAS:UniProtKB.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0008203; P:cholesterol metabolic process; NAS:UniProtKB.
 GO:0030301; P:cholesterol transport; NAS:UniProtKB.
 GO:0006893; P:Golgi to plasma membrane transport; NAS:UniProtKB. 
Interpro
 IPR000648; Oxysterol-bd.
 IPR018494; Oxysterol-bd_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF01237; Oxysterol_BP
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS01013; OSBP
 PS50003; PH_DOMAIN 
PRINTS