UniProt Accession

 ARK72_RAT; Q8CG45; Q6P765; Q8K435; Q9JM82 

Genbank Protein ID

 AF503514; BC061816; AJ271883; AB037424 

Genbank Nucleotide ID

 AAN03824.1; AAH61816.1; CAC81080.1; BAA90396.1 

Protein Name

 Aflatoxin B1 aldehyde reductase member 2 

Protein Synonyms/Alias

 rAFAR2; Succinic semialdehyde reductase; SSA reductase 

Gene Name

 Akr7a2 

Gene Synonyms/Alias

 Afar2; Aiar 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
120	KANPWDGKSLKPDSV	acetylation	[1]
123	PWDGKSLKPDSVRSQ	acetylation	[1]
136	SQLETSLKRLQCPRV	acetylation	[1]
244	AGGLLTGKYRYEDKD	acetylation	[1]
289	ALVEKALKTTYGTSA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein- binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Acts as a 2-carboxybenzaldehyde reductase. 

Sequence Annotation

 NP_BIND 179 180 NADP (By similarity).
 NP_BIND 234 244 NADP (By similarity).
 NP_BIND 326 334 NADP (By similarity).
 ACT_SITE 85 85 Proton donor (By similarity).
 BINDING 80 80 NADP (By similarity).
 BINDING 149 149 Substrate (By similarity).
 BINDING 205 205 NADP (By similarity).
 BINDING 258 258 NADP (By similarity).
 BINDING 268 268 Substrate (By similarity).
 BINDING 271 271 Substrate (By similarity).
 BINDING 367 367 Substrate (By similarity).
 MOD_RES 40 40 Phosphoserine (By similarity).
 MOD_RES 48 48 Phosphothreonine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Golgi apparatus; NADP; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:RGD.
 GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:RGD.
 GO:0019119; F:phenanthrene-9,10-epoxide hydrolase activity; IEA:Compara.
 GO:0044597; P:daunorubicin metabolic process; IEA:Compara.
 GO:0044598; P:doxorubicin metabolic process; IEA:Compara. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

  

PRINTS