UniProt Accession

 DUS22_HUMAN; Q9NRW4; B4DK56; Q59GW2; Q5VWR2; Q96AR1 

Genbank Protein ID

 AF424702; AF165519; AY249859; AK296402; AL365272; AL365272; BC016844; BC022847; AB208997 

Genbank Nucleotide ID

 AAL18850.1; AAF86649.1; AAP76376.1; BAG59068.1; CAH72534.1; CAH72535.1; AAH16844.1; AAH22847.1; BAD92234.1 

Protein Name

 Dual specificity protein phosphatase 22 

Protein Synonyms/Alias

 JNK-stimulatory phosphatase-1; JSP-1; Low molecular weight dual specificity phosphatase 2; LMW-DSP2; Mitogen-activated protein kinase phosphatase x; MAP kinase phosphatase x; MKP-x 

Gene Name

 DUSP22 

Gene Synonyms/Alias

 JSP1; LMWDSP2; MKPX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	GLYIGNFKDARDAEQ	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity). 

Sequence Annotation

 DOMAIN 65 133 Tyrosine-protein phosphatase.
 ACT_SITE 88 88 Phosphocysteine intermediate (By
 LIPID 2 2 N-myristoyl glycine.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Lipoprotein; Myristate; Nucleus; Polymorphism; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:RefGenome.
 GO:0006915; P:apoptotic process; TAS:ProtInc.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0000188; P:inactivation of MAPK activity; TAS:ProtInc.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
 GO:0046330; P:positive regulation of JNK cascade; IBA:RefGenome.
 GO:0042127; P:regulation of cell proliferation; IBA:RefGenome.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IBA:RefGenome. 

Interpro

 IPR020417; Atypical_DUSP.
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR000387; Tyr/Dual-sp_Pase. 

Pfam

 PF00782; DSPc 

SMART

 SM00195; DSPc 

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 

PRINTS

 PR01908; ADSPHPHTASE.