UniProt Accession

 KAD3_HUMAN; Q9UIJ7; B4DP58; D3DRI1; E7ET30; Q5VYW6; Q9H576; Q9HC01; Q9NPB4 

Genbank Protein ID

 AB021870; AF183419; AK001553; AK001951; AK027534; AK098205; AK298200; AL136231; AL353151; AL353151; AL136231; AL136231; AL353151; AL353151; AL136231; CH471071; CH471071; CH471071; BC013771 

Genbank Nucleotide ID

 BAA87913.1; AAG09688.1; BAA91753.1; BAA91996.1; BAB55183.1; BAG53592.1; BAG60470.1; CAI41262.1; CAI41262.1; CAH72282.1; CAH72282.1; CAI41260.1; CAI41260.1; CAH72283.1; CAH72283.1; EAW58779.1; EAW58780.1; EAW58781.1; AAH13771.1 

Protein Name

 GTP:AMP phosphotransferase AK3, mitochondrial 

Protein Synonyms/Alias

 Adenylate kinase 3; AK 3; Adenylate kinase 3 alpha-like 1 

Gene Name

 AK3 

Gene Synonyms/Alias

 AK3L1; AK6; AKL3L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
34	ITTHFELKHLSSGDL	acetylation	[1]
181	KAYEDQTKPVLEYYQ	acetylation	[2]
189	PVLEYYQKKGVLETF	acetylation	[1, 3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. 

Sequence Annotation

 NP_BIND 17 22 GTP (By similarity).
 NP_BIND 64 66 AMP (By similarity).
 NP_BIND 91 94 AMP (By similarity).
 NP_BIND 137 138 GTP (By similarity).
 REGION 37 66 NMPbind.
 REGION 127 164 LID.
 BINDING 38 38 AMP (By similarity).
 BINDING 43 43 AMP (By similarity).
 BINDING 98 98 AMP (By similarity).
 BINDING 128 128 GTP (By similarity).
 BINDING 161 161 AMP (By similarity).
 BINDING 172 172 AMP (By similarity).
 BINDING 201 201 GTP; via carbonyl oxygen (By similarity).
 MOD_RES 34 34 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; GTP-binding; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; ISS:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0046899; F:nucleoside triphosphate adenylate kinase activity; IDA:BHF-UCL.
 GO:0019201; F:nucleotide kinase activity; IEA:InterPro.
 GO:0046033; P:AMP metabolic process; IDA:BHF-UCL.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0046039; P:GTP metabolic process; IDA:BHF-UCL.
 GO:0046041; P:ITP metabolic process; IDA:BHF-UCL.
 GO:0046051; P:UTP metabolic process; IDA:BHF-UCL. 

Interpro

 IPR006259; Adenyl_kin_sub.
 IPR000850; Adenylate_kin.
 IPR007862; Adenylate_kinase_lid-dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK
 PF05191; ADK_lid 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.