CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000545
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Atrophin-1 
Protein Synonyms/Alias
 Dentatorubral-pallidoluysian atrophy protein homolog 
Gene Name
 Atn1 
Gene Synonyms/Alias
 Drpla 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
776FVPLEGSKLAKKRADacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. 
Sequence Annotation
 REGION 503 553 Involved in binding BAIAP2 (By
 REGION 864 879 Required for interaction with FAT1 (By
 MOTIF 16 32 Nuclear localization signal (By
 MOTIF 1018 1026 Nuclear export signal (By similarity).
 MOD_RES 34 34 Phosphoserine (By similarity).
 MOD_RES 77 77 Phosphoserine (By similarity).
 MOD_RES 79 79 Phosphoserine (By similarity).
 MOD_RES 101 101 Phosphoserine.
 MOD_RES 103 103 Phosphoserine (By similarity).
 MOD_RES 107 107 Phosphoserine (By similarity).
 MOD_RES 626 626 N6-acetyllysine (By similarity).
 MOD_RES 638 638 Phosphothreonine (By similarity).
 MOD_RES 646 646 Phosphoserine (By similarity).
 MOD_RES 724 724 Phosphoserine; by MAPK8 (By similarity).
 MOD_RES 731 731 Phosphoserine (By similarity).
 MOD_RES 733 733 Phosphoserine (By similarity).  
Keyword
 Acetylation; Cell junction; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Triplet repeat expansion. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1175 AA 
Protein Sequence
MKTRQNKDSM SMRSGRKKEA PGPREELRSR GRASPGGVST SSSDGKAEKS RQTAKKARIE 60
EPSAPKASKQ GRSEEISESE SEETSAPKKT KTEQELPRPQ SPSDLDSLDG RSINDDGSSD 120
PRDIDQDNRS TSPSIYSPGS VENDSDSSSG LSQGPARPYH PPPLFPPSPP PPDSTPRQPE 180
SGFEPHPSVP PTGYHAPMEP PTSRLFQGPP PGAPPTHPQL YPGNASGGVL SGPPMGPKGG 240
AAASSVGAPS GGKQHPPPTT PIPISSSGAS GAPPAKPPSA PVGGGSLPSA PPPASFPHVT 300
PNLPPPPALR PLNNASASPP GMGAQPIPGH LPSPHAMGQG MSGLPPGPEK GPTLAPSPHP 360
LPPASSSAPG PPMRYPYSSS SSSAAASSSS SSSSASQYPA SQALPSYPHS FPPPTSMSVS 420
NQPPKYTQPS LPSQAVWSQG PPPPPPYGRL LANNNTHPGP FPPTGGQSTA HPAAPTHHHH 480
QQQPQQQHHH GNSGPPPPGA YPHPLESSNS HHAHPYNMSP SLGSLRPYPP GPAHLPPPHG 540
QVSYNQAGPN GPPVSSSNSS GSSSQASYSC SHPSSSQGPQ GASYPFPPVP PVTTSSATLS 600
TVIATVASSP AGYKTASPPG PPQYSKRAPS PGSYKTATPP GYKPGSPPSF RTGTPPGYRG 660
TSPPAGPGTF KPGSPTVGPG PLPPAGPSSL SSLPPPPAAP TTGPPLTATQ IKQEPAEEYE 720
PPESPVPPAR SPSPPPKVVD VPSHASQSAR FNKHLDRGFN SCARSDLYFV PLEGSKLAKK 780
RADLVEKVRR EAEQRAREEK EREREREREK EREREKEREL ERSVKLAQEG RAPVECPSLG 840
PVPHRPPFEP GSAVATVPPY LGPDTPALRT LSEYARPHVM SPGNRNHPFY VPLGAVDPGL 900
LGYNVPALYS SDPAARERER EARERDLRDR LKPGFEVKPS ELEPLHGVPG PGLDPFPRHG 960
GLALQPGPPG LHPFPFHPSL GPLERERLAL AAGPALRPDM SYAERLAAER QHAERVAALG 1020
NDPLARLQML NVTPHHHQHS HIHSHLHLHQ QDAIHAASAS VHPLIDPLAS GSHLTRIPYP 1080
AGTLPNPLLP HPLHENEVLR HQLFAAPYRD LPASLSAPMS AAHQLQAMHA QSAELQRLAL 1140
EQQQWLHAHH PLHSVPLPAQ EDYYSHLKKE SDKPL 1175 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0050827; F:toxin receptor binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IGI:MGI.
 GO:0016477; P:cell migration; IDA:UniProtKB.
 GO:0030011; P:maintenance of cell polarity; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0051402; P:neuron apoptotic process; IEA:Compara.
 GO:0009404; P:toxin metabolic process; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR017993; Atrophin-1.
 IPR002951; Atrophin-like. 
Pfam
 PF03154; Atrophin-1 
SMART
  
PROSITE
  
PRINTS
 PR01222; ATROPHIN.