CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011401
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase receptor TYRO3 
Protein Synonyms/Alias
 Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF 
Gene Name
 TYRO3 
Gene Synonyms/Alias
 BYK; DTK; RSE; SKY; TIF 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
526TLGRMLGKGEFGSVRubiquitination[1]
582FDHPHVAKLVGVSLRubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. 
Sequence Annotation
 DOMAIN 41 128 Ig-like C2-type 1.
 DOMAIN 139 220 Ig-like C2-type 2.
 DOMAIN 225 317 Fibronectin type-III 1.
 DOMAIN 322 413 Fibronectin type-III 2.
 DOMAIN 518 790 Protein kinase.
 NP_BIND 524 532 ATP (By similarity).
 ACT_SITE 655 655 Proton acceptor (By similarity).
 BINDING 550 550 ATP (By similarity).
 MOD_RES 681 681 Phosphotyrosine; by autocatalysis (By
 MOD_RES 685 685 Phosphotyrosine; by autocatalysis (By
 MOD_RES 686 686 Phosphotyrosine; by autocatalysis (By
 MOD_RES 804 804 Phosphotyrosine; by autocatalysis (By
 CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).
 CARBOHYD 230 230 N-linked (GlcNAc...) (Potential).
 CARBOHYD 240 240 N-linked (GlcNAc...) (Potential).
 CARBOHYD 293 293 N-linked (GlcNAc...) (Potential).
 CARBOHYD 366 366 N-linked (GlcNAc...) (Potential).
 CARBOHYD 380 380 N-linked (GlcNAc...) (Potential).
 DISULFID 64 117
 DISULFID 160 203  
Keyword
 3D-structure; ATP-binding; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 890 AA 
Protein Sequence
MALRRSMGRP GLPPLPLPPP PRLGLLLAAL ASLLLPESAA AGLKLMGAPV KLTVSQGQPV 60
KLNCSVEGME EPDIQWVKDG AVVQNLDQLY IPVSEQHWIG FLSLKSVERS DAGRYWCQVE 120
DGGETEISQP VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IVWWRGTTKI 180
GGPAPSPSVL NVTGVTQSTM FSCEAHNLKG LASSRTATVH LQALPAAPFN ITVTKLSSSN 240
ASVAWMPGAD GRALLQSCTV QVTQAPGGWE VLAVVVPVPP FTCLLRDLVP ATNYSLRVRC 300
ANALGPSPYA DWVPFQTKGL APASAPQNLH AIRTDSGLIL EWEEVIPEAP LEGPLGPYKL 360
SWVQDNGTQD ELTVEGTRAN LTGWDPQKDL IVRVCVSNAV GCGPWSQPLV VSSHDRAGQQ 420
GPPHSRTSWV PVVLGVLTAL VTAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA 480
RSFNRERPER IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE 540
DGSFVKVAVK MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM 600
VILPFMKHGD LHAFLLASRI GENPFNLPLQ TLIRFMVDIA CGMEYLSSRN FIHRDLAARN 660
CMLAEDMTVC VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VQSDVWAFGV 720
TMWEIMTRGQ TPYAGIENAE IYNYLIGGNR LKQPPECMED VYDLMYQCWS ADPKQRPSFT 780
CLRMELENIL GQLSVLSASQ DPLYINIERA EEPTAGGSLE LPGRDQPYSG AGDGSGMGAV 840
GGTPSDCRYI LTPGGLAEQP GQAEHQPESP LNETQRLLLL QQGLLPHSSC 890 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0005635; C:nuclear envelope; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004716; F:receptor signaling protein tyrosine kinase activity; NAS:UniProtKB.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; NAS:UniProtKB.
 GO:0043277; P:apoptotic cell clearance; ISS:UniProtKB.
 GO:0021885; P:forebrain cell migration; ISS:UniProtKB.
 GO:0001779; P:natural killer cell differentiation; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
 GO:0045824; P:negative regulation of innate immune response; ISS:UniProtKB.
 GO:0051250; P:negative regulation of lymphocyte activation; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
 GO:0034122; P:negative regulation of toll-like receptor signaling pathway; ISS:UniProtKB.
 GO:0070050; P:neuron homeostasis; ISS:UniProtKB.
 GO:0042698; P:ovulation cycle; ISS:UniProtKB.
 GO:0014065; P:phosphatidylinositol 3-kinase cascade; NAS:UniProtKB.
 GO:0070527; P:platelet aggregation; ISS:UniProtKB.
 GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
 GO:0043491; P:protein kinase B signaling cascade; ISS:UniProtKB.
 GO:0032940; P:secretion by cell; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; ISS:UniProtKB.
 GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB.
 GO:0060068; P:vagina development; IEA:Compara. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF00041; fn3
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.