UniProt Accession

 COPD_HUMAN; P48444; B4E1X2; E9PEU4; Q52M80 

Genbank Protein ID

 X81197; X81198; AK304019; AP000941; BC093636; BC093638 

Genbank Nucleotide ID

 CAA57071.1; CAA57072.1; BAG64934.1; AAH93636.1; AAH93638.1 

Protein Name

 Coatomer subunit delta 

Protein Synonyms/Alias

 Archain; Delta-coat protein; Delta-COP 

Gene Name

 ARCN1 

Gene Synonyms/Alias

 COPD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	GLLAAFPKLMNTGKQ	ubiquitination	[1]
142	EMDSHEEKVFRAVRE	ubiquitination	[1]
211	IIETDKPKVAPAPAR	acetylation	[2]
233	LKLGAKGKEVDNFVD	acetylation	[3]
233	LKLGAKGKEVDNFVD	ubiquitination	[4]
241	EVDNFVDKLKSEGET	ubiquitination	[1]
243	DNFVDKLKSEGETIM	ubiquitination	[4]
256	IMSSSMGKRTSEATK	ubiquitination	[4]
309	MLRISDDKYGRIRLH	acetylation	[3]
336	THPNVDKKLFTAESL	ubiquitination	[1, 4]
347	AESLIGLKNPEKSFP	ubiquitination	[4]
351	IGLKNPEKSFPVNSD	ubiquitination	[1, 4]
363	NSDVGVLKWRLQTTE	ubiquitination	[1, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). 

Sequence Annotation

 DOMAIN 271 511 MHD.
 MOD_RES 233 233 N6-acetyllysine.
 MOD_RES 309 309 N6-acetyllysine.
 MOD_RES 493 493 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 511 AA 

Protein Sequence

Gene Ontology

 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0030126; C:COPI vesicle coat; ISS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0048205; P:COPI coating of Golgi vesicle; TAS:Reactome.
 GO:0006886; P:intracellular protein transport; TAS:ProtInc.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; TAS:Reactome. 

Interpro

 IPR022775; AP_mu_sigma_su.
 IPR008968; Clathrin_mu_C.
 IPR027059; Coatomer_dsu.
 IPR011012; Longin-like_dom. 

Pfam

 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS51072; MHD 

PRINTS