UniProt Accession

 GALK1_HUMAN; P51570; B2RC07 

Genbank Protein ID

 U26401; L76927; AK314890; BT007005; BC001166 

Genbank Nucleotide ID

 AAA96147.1; AAB51607.1; BAG37404.1; AAP35651.1; AAH01166.1 

Protein Name

 Galactokinase 

Protein Synonyms/Alias

 Galactose kinase 

Gene Name

 GALK1 

Gene Synonyms/Alias

 GALK 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	VLVGSPRKDGLVSLL	ubiquitination	[1]
217	LVPLSDPKLAVLITN	ubiquitination	[1]
252	EVARALGKESLREVQ	ubiquitination	[2]
272	AARDLVSKEGFRRAR	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Major enzyme for galactose metabolism. 

Sequence Annotation

 NP_BIND 134 144 ATP.
 REGION 43 46 Substrate binding.
 REGION 183 186 Substrate binding.
 ACT_SITE 186 186 Proton acceptor (By similarity).
 BINDING 236 236 Substrate.  

Keyword

 3D-structure; ATP-binding; Carbohydrate metabolism; Cataract; Complete proteome; Direct protein sequencing; Disease mutation; Galactose metabolism; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0004335; F:galactokinase activity; IDA:UniProtKB.
 GO:0005534; F:galactose binding; IDA:UniProtKB.
 GO:0019388; P:galactose catabolic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR000705; Galactokinase.
 IPR019741; Galactokinase_CS.
 IPR019539; GalKase_gal-bd.
 IPR013750; GHMP_kinase_C_dom.
 IPR006204; GHMP_kinase_N_dom.
 IPR006203; GHMP_knse_ATP-bd_CS.
 IPR006206; Mevalonate/galactokinase.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 

Pfam

 PF10509; GalKase_gal_bdg
 PF08544; GHMP_kinases_C
 PF00288; GHMP_kinases_N 

SMART

  

PROSITE

 PS00106; GALACTOKINASE
 PS00627; GHMP_KINASES_ATP 

PRINTS

 PR00473; GALCTOKINASE.
 PR00959; MEVGALKINASE.