CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030915
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin 6, isoform CRA_e 
Protein Synonyms/Alias
 Sorting nexin-6; cDNA FLJ58001, highly similar to Sorting nexin-6 
Gene Name
 SNX6 
Gene Synonyms/Alias
 hCG_2013610 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71RGKNKKEKLEDFFKNubiquitination[1, 2]
77EKLEDFFKNMVKSADubiquitination[2, 3, 4]
81DFFKNMVKSADGVIVubiquitination[1, 2]
92GVIVSGVKDVDDFFEubiquitination[1, 2, 5]
127DRMTRSHKSAADDYNubiquitination[1]
153QDSTDICKFFLKVSEubiquitination[2, 4, 6]
157DICKFFLKVSELFDKubiquitination[1, 2, 5]
164KVSELFDKTRKIEARubiquitination[1, 2]
179VSADEDLKLSDLLKYubiquitination[1, 2, 4]
185LKLSDLLKYYLRESQubiquitination[2]
195LRESQAAKDLLYRRSubiquitination[1, 2]
213VDYENANKALDKARAubiquitination[2]
221ALDKARAKNKDVLQAubiquitination[2]
223DKARAKNKDVLQAETubiquitination[2]
238SQQLCCQKFEKISESubiquitination[2]
241LCCQKFEKISESAKQubiquitination[2]
247EKISESAKQELIDFKubiquitination[1, 2]
254KQELIDFKTRRVAAFubiquitination[1, 2, 4]
263RRVAAFRKNLVELAEubiquitination[1, 2, 3, 4, 5]
274ELAELELKHAKGNLQubiquitination[2, 5]
277ELELKHAKGNLQLLQubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 294 AA 
Protein Sequence
MTTLTEIKLL PSLVLLVCCE YLAIFKKTVA MHEVFLCRVA AHPILRRDLN FHVFLEYNQD 60
LSVRGKNKKE KLEDFFKNMV KSADGVIVSG VKDVDDFFEH ERTFLLEYHN RVKDASAKSD 120
RMTRSHKSAA DDYNRIGSSL YALGTQDSTD ICKFFLKVSE LFDKTRKIEA RVSADEDLKL 180
SDLLKYYLRE SQAAKDLLYR RSRSLVDYEN ANKALDKARA KNKDVLQAET SQQLCCQKFE 240
KISESAKQEL IDFKTRRVAA FRKNLVELAE LELKHAKGNL QLLQNCLAVL NGDT 294 
Gene Ontology
  
Interpro
 IPR027267; AH/BAR-dom.
 IPR015404; Vps5_C. 
Pfam
 PF09325; Vps5 
SMART
  
PROSITE
  
PRINTS