UniProt Accession

 LDHA_CHICK; P00340 

Genbank Protein ID

 X53828 

Genbank Nucleotide ID

 CAA37824.1 

Protein Name

 L-lactate dehydrogenase A chain 

Protein Synonyms/Alias

 LDH-A 

Gene Name

 LDHA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Gallus gallus (Chicken) 

NCBI Taxa ID

 9031 

Lysine Modification

Position	Peptide	Type	References
243	DSAYEVIKLKGYTSW	acetylation	[1]

Reference

 [1] Stability of lactate dehydrogenases. I. Chemical modification of lysines.
 Müller J.
 Biochim Biophys Acta. 1981 Jul 28;669(2):210-5. [PMID: 6793082] 

Functional Description

  

Sequence Annotation

 NP_BIND 29 57 NAD (By similarity).
 ACT_SITE 193 193 Proton acceptor (By similarity).
 BINDING 99 99 NAD (By similarity).
 BINDING 106 106 Substrate (By similarity).
 BINDING 138 138 NAD or substrate (By similarity).
 BINDING 169 169 Substrate (By similarity).
 BINDING 248 248 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Glycolysis; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 332 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004459; F:L-lactate dehydrogenase activity; IEA:EC.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
 GO:0006090; P:pyruvate metabolic process; TAS:Reactome. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR011304; L-lactate_DH.
 IPR018177; L-lactate_DH_AS.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

 PS00064; L_LDH 

PRINTS

 PR00086; LLDHDRGNASE.