UniProt Accession

 C4BPB_HUMAN; P20851; A5JYP8; D3DT81; Q5VVR0; Q9BS25 

Genbank Protein ID

 L11244; L11245; M29964; EF613556; AL445493; AL445493; CH471100; CH471100; BC005378 

Genbank Nucleotide ID

 AAA35615.1; AAA35616.1; AAB59520.1; ABQ52216.1; CAH70780.1; CAH70781.1; EAW93504.1; EAW93506.1; AAH05378.1 

Protein Name

 C4b-binding protein beta chain 

Protein Synonyms/Alias

  

Gene Name

 C4BPB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
135	APPFPICKSRDCDPP	ubiquitination	[1]
192	SSALPVCKLIQEAPK	ubiquitination	[1]
199	KLIQEAPKPECEKAL	ubiquitination	[1]
204	APKPECEKALLAFQE	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. 

Sequence Annotation

 DOMAIN 21 78 Sushi 1.
 DOMAIN 79 136 Sushi 2.
 DOMAIN 137 193 Sushi 3.
 CARBOHYD 64 64 N-linked (GlcNAc...).
 CARBOHYD 71 71 N-linked (GlcNAc...).
 CARBOHYD 98 98 N-linked (GlcNAc...).
 CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
 CARBOHYD 154 154 N-linked (GlcNAc...) (Potential).
 DISULFID 23 63 By similarity.
 DISULFID 49 76 By similarity.
 DISULFID 81 121 By similarity.
 DISULFID 107 134 By similarity.
 DISULFID 139 179 By similarity.
 DISULFID 165 191 By similarity.
 DISULFID 202 202 Interchain (with alpha chain)
 DISULFID 216 216 Interchain (with alpha chain)  

Keyword

 Alternative splicing; Complement pathway; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Innate immunity; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Sushi. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:ProtInc.
 GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0030449; P:regulation of complement activation; TAS:Reactome. 

Interpro

 IPR000436; Sushi_SCR_CCP. 

Pfam

 PF00084; Sushi 

SMART

 SM00032; CCP 

PROSITE

 PS50923; SUSHI 

PRINTS