CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023193
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal transduction protein CBL-C 
Protein Synonyms/Alias
 RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C 
Gene Name
 CBLC 
Gene Synonyms/Alias
 CBL3; RNF57 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
90YLANLEAKSRQVAALubiquitination[1]
257RLQACRDKPGSYIFRubiquitination[1]
313FYLYPDGKTHNPDLTubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Regulator of EGFR mediated signal transduction. 
Sequence Annotation
 DOMAIN 7 321 Cbl-PTB.
 ZN_FING 351 390 RING-type.
 REGION 7 145 4H.
 REGION 146 218 EF-hand-like.
 REGION 219 321 SH2-like.
 REGION 322 350 Linker.
 MOTIF 89 92 Nuclear localization signal (Potential).
 BINDING 264 264 Phosphotyrosine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Calcium; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MALAVAPWGR QWEEARALGR AVRMLQRLEE QCVDPRLSVS PPSLRDLLPR TAQLLREVAH 60
SRRAAGGGGP GGPGGSGDFL LIYLANLEAK SRQVAALLPP RGRRSANDEL FRAGSRLRRQ 120
LAKLAIIFSH MHAELHALFP GGKYCGHMYQ LTKAPAHTFW RESCGARCVL PWAEFESLLG 180
TCHPVEPGCT ALALRTTIDL TCSGHVSIFE FDVFTRLFQP WPTLLKNWQL LAVNHPGYMA 240
FLTYDEVQER LQACRDKPGS YIFRPSCTRL GQWAIGYVSS DGSILQTIPA NKPLSQVLLE 300
GQKDGFYLYP DGKTHNPDLT ELGQAEPQQR IHVSEEQLQL YWAMDSTFEL CKICAESNKD 360
VKIEPCGHLL CSCCLAAWQH SDSQTCPFCR CEIKGWEAVS IYQFHGQATA EDSGNSSDQE 420
GRELELGQVP LSAPPLPPRP DLPPRKPRNA QPKVRLLKGN SPPAALGPQD PAPA 474 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005154; F:epidermal growth factor receptor binding; IDA:BHF-UCL.
 GO:0001784; F:phosphotyrosine binding; IDA:BHF-UCL.
 GO:0017124; F:SH3 domain binding; IDA:BHF-UCL.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:BHF-UCL.
 GO:0008270; F:zinc ion binding; TAS:ProtInc.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
 GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IDA:BHF-UCL.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:BHF-UCL. 
Interpro
 IPR024162; Adaptor_Cbl.
 IPR014741; Adaptor_Cbl_EF_hand-like.
 IPR003153; Adaptor_Cbl_N_hlx.
 IPR014742; Adaptor_Cbl_SH2-like.
 IPR024159; Cbl_PTB.
 IPR011992; EF-hand-like_dom.
 IPR000980; SH2.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF02262; Cbl_N
 PF02761; Cbl_N2
 PF02762; Cbl_N3 
SMART
 SM00184; RING
 SM00252; SH2 
PROSITE
 PS51506; CBL_PTB
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS