CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021406
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger CCHC domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 ZCCHC4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82FFQWEDEKLSGARLAubiquitination[1]
113QCVERYLKFIELPLTubiquitination[1, 2]
168LYPLENKKTNAQYLFubiquitination[1]
465CPNIATSKRANKAVRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May be a methyltransferase. 
Sequence Annotation
 ZN_FING 395 447 DHHC-type.
 ZN_FING 443 460 CCHC-type.  
Keyword
 Alternative splicing; Complete proteome; Metal-binding; Methyltransferase; Polymorphism; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 513 AA 
Protein Sequence
MAASRNGFEA VEAEGSAGCR GSSGMEVVLP LDPAVPAPLC PHGPTLLFVK VTQGKEETRR 60
FYACSACRDR KDCNFFQWED EKLSGARLAA REAHNRRCQP PLSRTQCVER YLKFIELPLT 120
QRKFCQTCQQ LLLPDDWGQH SEHQVLGNVS ITQLRRPSQL LYPLENKKTN AQYLFADRSC 180
QFLVDLLSAL GFRRVLCVGT PRLHELIKLT ASGDKKSNIK SLLLDIDFRY SQFYMEDSFC 240
HYNMFNHHFF DGKTALEVCR AFLQEDKGEG IIMVTDPPFG GLVEPLAITF KKLIAMWKEG 300
QSQDDSHKEL PIFWIFPYFF ESRICQFFPS FQMLDYQVDY DNHALYKHGK TGRKQSPVRI 360
FTNIPPNKII LPTEEGYRFC SPCQRYVSLE NQHCELCNSC TSKDGRKWNH CFLCKKCVKP 420
SWIHCSICNH CAVPDHSCEG PKHGCFICGE LDHKRSTCPN IATSKRANKA VRKQKQRKSN 480
KMKMETTKGQ SMNHTSATRR KKRRERAHQY LGS 513 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR002052; DNA_methylase_N6_adenine_CS.
 IPR019369; N6_adenine_Mtase-rel_euk.
 IPR001878; Znf_CCHC.
 IPR001594; Znf_DHHC_palmitoyltrfase.
 IPR010666; Znf_GRF. 
Pfam
 PF10237; N6-adenineMlase
 PF06839; zf-GRF 
SMART
 SM00343; ZnF_C2HC 
PROSITE
 PS00092; N6_MTASE
 PS50158; ZF_CCHC
 PS50216; ZF_DHHC 
PRINTS