CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020151
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metastasis-associated protein MTA3 
Protein Synonyms/Alias
  
Gene Name
 MTA3 
Gene Synonyms/Alias
 KIAA1266 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
61TLIMLADKHAKEIEEubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. 
Sequence Annotation
 DOMAIN 1 147 BAH.
 DOMAIN 148 259 ELM2.
 DOMAIN 266 318 SANT.
 ZN_FING 379 406 GATA-type; atypical.
 MOD_RES 455 455 Phosphothreonine.
 MOD_RES 457 457 Phosphoserine.
 MOD_RES 519 519 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 594 AA 
Protein Sequence
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD ISNTLIMLAD 60
KHAKEIEEES ETTVEADLTD KQKHQLKHRE LFLSRQYESL PATHIRGKCS VALLNETESV 120
LSYLDKEDTF FYSLVYDPSL KTLLADKGEI RVGPRYQADI PEMLLEGESD EREQSKLEVK 180
VWDPNSPLTD RQIDQFLVVA RAVGTFARAL DCSSSVRQPS LHMSAAAASR DITLFHAMDT 240
LYRHSYDLSS AISVLVPLGG PVLCRDEMEE WSASEASLFE EALEKYGKDF NDIRQDFLPW 300
KSLTSIIEYY YMWKTTDRYV QQKRLKAAEA ESKLKQVYIP TYSKPNPNQI STSNGKPGAV 360
NGAVGTTFQP QNPLLGRACE SCYATQSHQW YSWGPPNMQC RLCAICWLYW KKYGGLKMPT 420
QSEEEKLSPS PTTEDPRVRS HVSRQAMQGM PVRNTGSPKS AVKTRQAFFL HTTYFTKFAR 480
QVCKNTLRLR QAARRPFVAI NYAAIRAEYA DRHAELSGSP LKSKSTRKPL ACIIGYLEIH 540
PAKKPNVIRS TPSLQTPTTK RMLTTPNHTS LSILGKRNYS HHNGLDELTC CVSD 594 
Gene Ontology
 GO:0008278; C:cohesin complex; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016581; C:NuRD complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Compara. 
Interpro
 IPR001025; BAH_dom.
 IPR000949; ELM2_dom.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR000679; Znf_GATA. 
Pfam
 PF01426; BAH
 PF01448; ELM2
 PF00320; GATA 
SMART
 SM00439; BAH
 SM00717; SANT
 SM00401; ZnF_GATA 
PROSITE
 PS51038; BAH
 PS51156; ELM2
 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2
 PS51293; SANT 
PRINTS