UniProt Accession

 E7EQ01_HUMAN; E7EQ01 

Genbank Protein ID

 AC007256; AC007283 

Genbank Nucleotide ID

  

Protein Name

 Caspase-8 subunit p10 

Protein Synonyms/Alias

  

Gene Name

 CASP8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	ESNLSFLKELLFRIN	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 116 AA 

Protein Sequence

Gene Ontology

 GO:0031265; C:CD95 death-inducing signaling complex; IEA:Compara.
 GO:0044297; C:cell body; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0030690; C:Noc1p-Noc2p complex; IEA:Compara.
 GO:0004197; F:cysteine-type endopeptidase activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0030225; P:macrophage differentiation; IEA:Compara.
 GO:0001841; P:neural tube formation; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0032025; P:response to cobalt ion; IEA:Compara.
 GO:0009409; P:response to cold; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR001875; DED.
 IPR002398; Pept_C14_p45. 

Pfam

 PF01335; DED 

SMART

 SM00031; DED 

PROSITE

 PS50168; DED 

PRINTS