UniProt Accession

 PTPM1_HUMAN; Q8WUK0; E9PAT8; Q7Z557; Q96CR2; Q9BXV8 

Genbank Protein ID

 AY333987; AC090559; AC104942; BC014048; BC020242; BC073798; AF277187 

Genbank Nucleotide ID

 AAP94732.1; AAH14048.1; AAH20242.1; AAK07545.1 

Protein Name

 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 

Protein Synonyms/Alias

 PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1 

Gene Name

 PTPMT1 

Gene Synonyms/Alias

 MOSP; PLIP; PNAS-129 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
164	EAVRAIAKIRSYIHI	ubiquitination	[1]
180	PGQLDVLKEFHKQIT	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). 

Sequence Annotation

 DOMAIN 109 183 Tyrosine-protein phosphatase.
 ACT_SITE 132 132 Phosphocysteine intermediate (By  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Lipid biosynthesis; Lipid metabolism; Membrane; Mitochondrion; Mitochondrion inner membrane; Phospholipid biosynthesis; Phospholipid metabolism; Protein phosphatase; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IBA:RefGenome.
 GO:0008962; F:phosphatidylglycerophosphatase activity; ISS:UniProtKB.
 GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IBA:RefGenome.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:RefGenome.
 GO:0032049; P:cardiolipin biosynthetic process; ISS:UniProtKB.
 GO:0046855; P:inositol phosphate dephosphorylation; IBA:RefGenome.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 

Interpro

 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR024950; DUSP.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS. 

Pfam

 PF00782; DSPc 

SMART

  

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 

PRINTS