CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028429
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear receptor coactivator 3 
Protein Synonyms/Alias
  
Gene Name
 Ncoa3 
Gene Synonyms/Alias
 mCG_14623 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
608PRGPLESKGHKKLLQacetylation[1, 2]
611PLESKGHKKLLQLLTacetylation[1, 2]
612LESKGHKKLLQLLTCacetylation[1, 2]
679EKHRILHKLLQNGNSacetylation[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1402 AA 
Protein Sequence
MSGLGESSLD PLAAESRKRK LPCDAPGQGL VYSGEKWRRE QESKYIEELA ELISANLSDI 60
DNFNVKPDKC AILKETVRQI RQIKEQGKTI SSDDDVQKAD VSSTGQGVID KDSLGPLLLQ 120
ALDGFLFVVN RDGNIVFVSE NVTQYLQYKQ EDLVNTSVYS ILHEQDRKDF LKHLPKSTVN 180
GVSWTNENQR QKSHTFNCRM LMKTHDILED VNASPETRQR YETMQCFALS QPRAMLEEGE 240
DLQCCMICVA RRVTAPFPSS PESFITRHDL SGKVVNIDTN SLRSSMRPGF EDIIRRCIQR 300
FFSLNDGQSW SQKRHYQEAY VHGHAETPVY RFSLADGTIV SAQTKSKLFR NPVTNDRHGF 360
ISTHFLQREQ NGYRPNPNPA GQGIRPPAAG CGVSMSPNQN VQMMGSRTYG VPDPSNTGQM 420
GGARYGASSS VASLTPGQSL QSPSSYQNSS YGLSMSSPPH GSPGLGPNQQ NIMISPRNRG 480
SPKMASHQFS PAAGAHSPMG PSGNTGSHSF SSSSLSALQA ISEGVGTSLL STLSSPGPKL 540
DNSPNMNISQ PSKVSGQDSK SPLGLYCEQN PVESSVCQSN SRDHPSEKES KESSGEVSET 600
PRGPLESKGH KKLLQLLTCS SDDRGHSSLT NSPLDPNCKD SSVSVTSPSG VSSSTSGTVS 660
STSNVHGSLL QEKHRILHKL LQNGNSPAEV AKITAEATGK DTSSTASCGE GTTRQEQLSP 720
KKKENNALLR YLLDRDDPSD VLAKELQPQA DSGDSKLSQC SCSTNPSSGQ EKDPKIKTET 780
NEEVSGDLDN LDAILGDLTS SDFYNNPTNG GHPGAKQQMF AGPSSLGLRS PQPVQSVRPP 840
YNRAVSLDSP VSVGSGPPVK NVSAFPGLPK QPILAGNPRM MDSQENYGAN MGPNRNVPVN 900
PTSSPGDWGL ANSRASRMEP LASSPLGRTG ADYSATLPRP AMGGSVPTLP LRSNRLPGAR 960
PSLQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QMLQMRTGEI PMGMGVNPYS PAVPSNQPGS 1020
WPEGMLSMEQ GPHGSQNRPL LRNSLDDLLG PPSNAEGQSD ERALLDQLHT LLSNTDATGL 1080
EEIDRALGIP ELVNQGQALE SKQDVFQGQE AAVMMDQKAA LYGQTYPAQG PPLQGGFNLQ 1140
GQSPSFNSMM GQISQQGSFP LQGMHPRAGL VRPRTNTPKQ LRMQLQQRLQ GQQFLNQSRQ 1200
ALEMKMENPA GTAVMRPMMP QAFFNAQMAA QQKRELMSHH LQQQRMAMMM SQPQPQAFSP 1260
PPNVTASPSM DGVLAGSAMP QAPPQQFPYP ANYGMGQPPE PAFGRGSSPP SAMMSSRMGP 1320
SQNAMVQHPQ PTPMYQPSDM KGWPSGNLAR NGSFPQQQFA PQGNPAAYNM VHMNSSGGHL 1380
GQMAMTPMPM SGMPMGPDQK YC 1402 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; IEA:InterPro.
 GO:0048589; P:developmental growth; IMP:MGI.
 GO:0016573; P:histone acetylation; IEA:GOC.
 GO:0060713; P:labyrinthine layer morphogenesis; IGI:MGI.
 GO:0060744; P:mammary gland branching involved in thelarche; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0060068; P:vagina development; IMP:MGI. 
Interpro
 IPR011598; bHLH_dom.
 IPR010011; DUF1518.
 IPR009110; Nuc_rcpt_coact.
 IPR014920; Nuc_rcpt_coact_Ncoa-typ.
 IPR017426; Nuclear_rcpt_coactivator.
 IPR000014; PAS.
 IPR013767; PAS_fold.
 IPR014710; RmlC-like_jellyroll.
 IPR014935; SRC-1.
 IPR008955; Src1_rcpt_coact. 
Pfam
 PF07469; DUF1518
 PF08815; Nuc_rec_co-act
 PF00989; PAS
 PF08832; SRC-1 
SMART
 SM00353; HLH
 SM00091; PAS 
PROSITE
 PS50888; BHLH
 PS50112; PAS 
PRINTS