CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015939
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hepatoma-derived growth factor-related protein 2 
Protein Synonyms/Alias
 HRP-2; Hepatoma-derived growth factor 2; HDGF-2 
Gene Name
 HDGFRP2 
Gene Synonyms/Alias
 HDGF2; UNQ785/PRO1604 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39AVKPPPNKYPIFFFGacetylation[1]
487SEIKFALKVDSPDVKubiquitination[2, 3]
494KVDSPDVKRCLNALEubiquitination[2, 4]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 DOMAIN 7 64 PWWP.
 MOD_RES 137 137 Phosphoserine.
 MOD_RES 230 230 Phosphoserine.
 MOD_RES 232 232 Phosphoserine.
 MOD_RES 234 234 Phosphoserine.
 MOD_RES 236 236 Phosphoserine (By similarity).
 MOD_RES 240 240 Phosphoserine.
 MOD_RES 366 366 Phosphoserine.
 MOD_RES 369 369 Phosphoserine.
 MOD_RES 370 370 Phosphoserine.
 MOD_RES 395 395 Phosphoserine.
 MOD_RES 396 396 Phosphoserine.
 MOD_RES 397 397 Phosphoserine.
 MOD_RES 399 399 Phosphoserine.
 MOD_RES 454 454 Phosphoserine.
 MOD_RES 490 490 Phosphoserine.
 MOD_RES 625 625 Phosphoserine.
 MOD_RES 633 633 Phosphoserine.
 MOD_RES 634 634 Phosphoserine.
 MOD_RES 640 640 Phosphoserine (By similarity).
 MOD_RES 652 652 Phosphoserine.
 MOD_RES 664 664 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 671 AA 
Protein Sequence
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET AFLGPKDLFP 60
YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS SDSEAPEANP ADGSDADEDD 120
EDRGVMAVTA VTATAASDRM ESDSDSDKSS DNSGLKRKTP ALKMSVSKRA RKASSDLDQA 180
SVSPSEEENS ESSSESEKTS DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS 240
DGAKPEPVAM ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS 300
SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK ERRRERADRG 360
EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE PEAELEREAK KSAKKPQSSS 420
TEPARKPGQK EKRVRPEEKQ QAKPVKVERT RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS 480
EIKFALKVDS PDVKRCLNAL EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA 540
EVYTRLKSRV LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA 600
PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDS VREGPDLDRP GSDRQERERA 660
RGDSEALDEE S 671 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR021567; LEDGF.
 IPR000313; PWWP.
 IPR017923; TFIIS_N. 
Pfam
 PF11467; LEDGF
 PF00855; PWWP 
SMART
 SM00293; PWWP 
PROSITE
 PS50812; PWWP 
PRINTS