UniProt Accession

 STX4_MOUSE; P70452; Q3TSL5; Q3UKQ8; Q80WT8 

Genbank Protein ID

 U76832; AK145909; AK161971; BC005791; BC011491; BC052023 

Genbank Nucleotide ID

 AAB18991.1; BAE26743.1; BAE36660.1; AAH05791.1; AAH11491.1; AAH52023.1 

Protein Name

 Syntaxin-4 

Protein Synonyms/Alias

  

Gene Name

 Stx4 

Gene Synonyms/Alias

 Stx4a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
64	SKVRELEKQQVTILA	ubiquitination	[1]
102	REVRAQLKAIEPQKE	ubiquitination	[1]
108	LKAIEPQKEEADENY	ubiquitination	[1]
243	EMINRIEKNILSSAD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. 

Sequence Annotation

 DOMAIN 200 262 t-SNARE coiled-coil homology.
 REGION 154 298 Interaction with CENPF.
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 29 29 Phosphoserine.
 MOD_RES 117 117 Phosphoserine.  

Keyword

 3D-structure; Cell membrane; Coiled coil; Complete proteome; Membrane; Neurotransmitter transport; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043219; C:lateral loop; IDA:BHF-UCL.
 GO:0035749; C:myelin sheath adaxonal region; IDA:BHF-UCL.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0031201; C:SNARE complex; ISS:UniProtKB.
 GO:0042581; C:specific granule; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016079; P:synaptic vesicle exocytosis; TAS:MGI. 

Interpro

 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE
 PF00804; Syntaxin 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS