UniProt Accession

 H7C0E2_HUMAN; H7C0E2 

Genbank Protein ID

 AC007256; AC007283 

Genbank Nucleotide ID

  

Protein Name

 Caspase-8 subunit p10 

Protein Synonyms/Alias

  

Gene Name

 CASP8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
123	TSQFTGLKCPSLAGK	ubiquitination	[1]
130	KCPSLAGKPKVFFIQ	ubiquitination	[1]
240	DDKKNMGKQMPQPTF	ubiquitination	[1, 2]
251	QPTFTLRKKLVFPSD	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 258 AA 

Protein Sequence

Gene Ontology

 GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0042981; P:regulation of apoptotic process; IEA:InterPro. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR001875; DED.
 IPR011600; Pept_C14_cat.
 IPR001309; Pept_C14_ICE_p20.
 IPR016129; Pept_C14_ICE_p20_AS.
 IPR002138; Pept_C14_p10.
 IPR002398; Pept_C14_p45.
 IPR015917; Pept_C14_p45_core. 

Pfam

 PF01335; DED
 PF00656; Peptidase_C14 

SMART

 SM00115; CASc 

PROSITE

 PS01122; CASPASE_CYS
 PS01121; CASPASE_HIS
 PS50207; CASPASE_P10
 PS50208; CASPASE_P20
 PS50168; DED 

PRINTS

 PR00376; IL1BCENZYME.