CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011802
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UBA domain-containing protein RUP1 
Protein Synonyms/Alias
  
Gene Name
 RUP1 
Gene Synonyms/Alias
 YOR138C; YOR3332c 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
273LEPQLRSKLADSEHLubiquitination[1]
489AKQIASLKDTLNSARubiquitination[2]
499LNSARAAKMEEYKDLubiquitination[2]
635EDDQNSLKTLRSQFFubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
 Modulates the activity of the RSP5 HECT ubiquitin- protein ligase through its mediation of the interaction between RSP5 and the deubiquitinase UBP2. Involved in regulation of cell wall homeostasis. 
Sequence Annotation
 DOMAIN 1 41 UBA.
 MOD_RES 56 56 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 671 AA 
Protein Sequence
MMDNQAVKSL LEMGIPHEVA VDALQRTGGN LEAAVNFIFS NELPEQAEMG EENDGSQPRI 60
SENKIVAGTK PCDVPNNGDQ DIDMPDVSGV DVDYDDDEDI TDERSGSNST SGCRVTAQNY 120
DRYSISETSI PPPSYSIVQH NEFKSNVGDP TVVLPLPLNS LIESYFGLFA LLTAVYFPHV 180
FLKPDFKDLN YRADWFKGSS FTEPKYRLAY CEAEDGSTTS EIVLASGPNE GLQPHLLWQL 240
QKLISVVNTR KCERAFVSAK VFTSSLEPQL RSKLADSEHL YEVLPAFIKS LAVDLEMCPG 300
IRDRETRSLF ISSALHTPNK NEPPMETFLS LFHFLPEEYD SNLYKMFNVL LYPEEEEEEE 360
DVIRGGEQEE ARYVEPENTL KEVAPVLTIL FNELETNTES VSLPNGVDIP LEFYPQLYTK 420
QCKDQLIRHI ISKRKQARTR SRCLLQEINE LKSYQGKNIS TILESTLAYL QTIPDDANNE 480
AAKQIASLKD TLNSARAAKM EEYKDLASKL HGEWNLSHPE THIINTAKQL GLIENPYILT 540
MAALSPYSYF IRSRNGAWSW IQSNTLGTEF KVKKCSSPSV VQEAIKHGTK YASETPLMFI 600
YCEEGKIPTE EVVAEALKSN SGCLKFAEDD QNSLKTLRSQ FFDGMGDPEQ ATNNINNGND 660
NDNDDDIDSD N 671 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0016579; P:protein deubiquitination; IMP:SGD. 
Interpro
 IPR024871; Rup1.
 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N.
 IPR015940; UBA/transl_elong_EF1B_N_euk. 
Pfam
 PF00627; UBA 
SMART
 SM00165; UBA 
PROSITE
 PS50030; UBA 
PRINTS