UniProt Accession

 CERS5_HUMAN; Q8N5B7 

Genbank Protein ID

 BC032565 

Genbank Nucleotide ID

 AAH32565.1 

Protein Name

 Ceramide synthase 5 

Protein Synonyms/Alias

 CerS5; LAG1 longevity assurance homolog 5 

Gene Name

 CERS5 

Gene Synonyms/Alias

 LASS5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
113	KRLEGLSKQLDWNVR	ubiquitination	[1, 2]
121	QLDWNVRKIQCWFRH	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner (By similarity). 

Sequence Annotation

 DOMAIN 139 340 TLC.
 DNA_BIND 75 136 Homeobox.
 CARBOHYD 26 26 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; DNA-binding; Endoplasmic reticulum; Glycoprotein; Homeobox; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleus; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0050291; F:sphingosine N-acyltransferase activity; IDA:HGNC.
 GO:0046513; P:ceramide biosynthetic process; IDA:HGNC.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR016439; Longevity_assurance_LAG1_LAC1.
 IPR006634; TLC-dom. 

Pfam

 PF00046; Homeobox
 PF03798; TRAM_LAG1_CLN8 

SMART

 SM00389; HOX
 SM00724; TLC 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2
 PS50922; TLC 

PRINTS