CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036905
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Target of Myb protein 1 
Protein Synonyms/Alias
  
Gene Name
 TOM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
273FRTGQTTKAPSEAEPubiquitination[1, 2, 3, 4]
344SSLADQRKEVKYEAPubiquitination[1, 2, 5, 6]
347ADQRKEVKYEAPQATubiquitination[1, 2, 3, 4, 5, 6, 7, 8]
414KFLEERAKAADRLPNubiquitination[3, 6]
446PRKKTQEKDDDMLFAubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [8] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 454 AA 
Protein Sequence
MAPCRARTGP STWRSATSST RRRKGARRHL SALQVLETCV KNCGHRFHVL VASQDFVESV 60
LVRTILPKNN PPTIVHDKVL NLIQSWADAF RSSPDLTGVV TIYEDLRRKG LEFPMTDLDM 120
LSPIHTPQRT VFNSETQSGQ DSVGTDSSQQ EDSGQHAAPL PAPPILSGDT PIAPTPEQIG 180
KLRSELEMVS GNVRVMSEML TELVPTQAEP ADLELLQELN RTCRAMQQRV LELIPQIANE 240
QLTEELLIVN DNLNNVFLRH ERFERFRTGQ TTKAPSEAEP AADLIDMGPD PAATGNLSSQ 300
LAGMNLGSSS VRAGLQSLEA SGRLEDEFDM FALTRGSSLA DQRKEVKYEA PQATDGLAGA 360
LDARQQSTGA IPVTQACLME DIEQWLSTDV GNDAEEPKGV TSEEFDKFLE ERAKAADRLP 420
NLSSPSAEGP PGPPSGPAPR KKTQEKDDDM LFAL 454 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR008942; ENTH_VHS.
 IPR004152; GAT.
 IPR014645; TOM1.
 IPR002014; VHS. 
Pfam
 PF03127; GAT
 PF00790; VHS 
SMART
  
PROSITE
 PS50909; GAT
 PS50179; VHS 
PRINTS