CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016865
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SAFB-like transcription modulator 
Protein Synonyms/Alias
 Modulator of estrogen-induced transcription; SAF-like transcription modulator 
Gene Name
 Sltm 
Gene Synonyms/Alias
 Met 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
625LVRFERLKQAVEFRRubiquitination[1]
1021RGSSSGFKPFKSGPPacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. 
Sequence Annotation
 DOMAIN 22 56 SAP.
 DOMAIN 384 462 RRM.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 93 93 Phosphoserine (By similarity).
 MOD_RES 97 97 Phosphoserine (By similarity).
 MOD_RES 139 139 Phosphoserine.
 MOD_RES 144 144 Phosphoserine (By similarity).
 MOD_RES 289 289 Phosphoserine.
 MOD_RES 401 401 N6-acetyllysine (By similarity).
 MOD_RES 421 421 Phosphoserine (By similarity).
 MOD_RES 549 549 Phosphoserine (By similarity).
 MOD_RES 550 550 Phosphoserine (By similarity).
 MOD_RES 552 552 Phosphoserine.
 MOD_RES 747 747 Phosphoserine (By similarity).
 MOD_RES 797 797 Phosphoserine (By similarity).
 MOD_RES 906 906 Phosphoserine (By similarity).
 MOD_RES 999 999 Phosphoserine.
 MOD_RES 1011 1011 Phosphoserine (By similarity).
 MOD_RES 1016 1016 Phosphoserine (By similarity).
 MOD_RES 1018 1018 Phosphoserine (By similarity).
 MOD_RES 1021 1021 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; RNA-binding; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1031 AA 
Protein Sequence
MAAAAGAVVA SAASGPAEGK KITELRVIDL RSELKRRNLD INGVKTVLVS RLKQAIEEEG 60
GDPDNIELTV STDTPNKKPT KGKGKKQEAD ELSGDASVED DSFVKDCELE NQETHDQDGN 120
EELKDLEEFG ENEEEIVHSQ ELLSTEENKT TQEFVEAEAI EDREKEDIES QETEAQEGED 180
DTFLTAQDGE EEENEKDIAG SGDGTQEVSK PLPSEGSLAE ADHTAHEEME ANATGKEAED 240
DNISVTIQAE DAITLDFDGD DLLETGKNVK ITDSEASKPK DVQDAIAQSP EKEAKDYEMN 300
PNHKDGKKED SVKGEPVEKE ARESAKKAES GDKEKDTLKK GPSSTGASGQ AKSSSKESKD 360
SKTSSKDDKG STGSAGGSSG SSTKNIWVSG LSSNTKAADL KNLFGKYGKV LSAKVVTNAR 420
SPGAKCYGIV TMSSSTEVSR CVAHLHRTEL HGQLISVEKV KGDPSKKEMK KENDEKSSSR 480
SAGDKKNASD RSAKTQASIK KEEKRSSEKS EKKESKDTKK IEKDEKNDDG PSGQTSESLK 540
KSEEKKRISS KSPGHMVILN QTKGDHCRPS RRGRYEKGHG RSKEKERASL DKKRDKDYRR 600
KEILPFEKMK EQRLREHLVR FERLKQAVEF RRRKEIAERE RRERERIRII REREERERLQ 660
RERERLEIER QKLERERMER ERLERERIRI EQERRREAER IAREREELRR QQQQLRYEQE 720
KRNSLKRPRD VDHRRDDPYW SENKKLSLDT EARFGHGSDY RQQSRFLDFS HRERARFPDT 780
ASVQSSFERR ERFVGQSEGK KPRPAARREE PSFERYPKNF SDSRRNEPPP PRNELRETDR 840
REVRGERDER RTVILHDRPE VAHPRHPRET VPNPSRPTSW KSEANMSTEK RESRVERPER 900
SGREVSGHTV RGAPPGNRSS ASGYGTREGE RGVIADRGSG TQHYPEERHV VERHGRDTSG 960
PRKEWHGPPS QGPSYHDTRR MGDGRAGAGM ITQHSSTASP VNRIVQMSGN SLPRGSSSGF 1020
KPFKSGPPRR F 1031 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR003034; SAP_dom. 
Pfam
 PF00076; RRM_1
 PF02037; SAP 
SMART
 SM00360; RRM
 SM00513; SAP 
PROSITE
 PS50102; RRM
 PS50800; SAP 
PRINTS