CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034021
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin thioesterase OTUB1 
Protein Synonyms/Alias
  
Gene Name
 Otub1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
29LELSVLYKEYAEDDNubiquitination[1]
41DDNIYQQKIKDLHKKubiquitination[1]
54KKYSYIRKTRPDGNCubiquitination[1]
79EALLDDSKELQRFKAubiquitination[1]
158GYLQRESKFFEHFIEacetylation[2]
158GYLQRESKFFEHFIEubiquitination[1]
171IEGGRTVKEFCQQEVacetylation[2]
171IEGGRTVKEFCQQEVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 241 AA 
Protein Sequence
MAQQDRIQQE IAVQNPLVSE RLELSVLYKE YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN 60
CFYRAFGFSH LEALLDDSKE LQRFKAVSAK SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE 120
KQTSVADLLA SFNDQSTSDY LVVYLRLLTS GYLQRESKFF EHFIEGGRTV KEFCQQEVEP 180
MCKESDHIHI IALAQALSVS IQVEYMDRGE GGTTNPHVFP EGSEPKVYLL YRPGHYDILY 240
K 241 
Gene Ontology
 GO:0019784; F:NEDD8-specific protease activity; IEA:Compara.
 GO:0008242; F:omega peptidase activity; IEA:InterPro.
 GO:0004843; F:ubiquitin-specific protease activity; IEA:Compara.
 GO:2000780; P:negative regulation of double-strand break repair; IEA:Compara.
 GO:1901315; P:negative regulation of histone H2A K63-linked ubiquitination; IEA:Compara.
 GO:0071108; P:protein K48-linked deubiquitination; IEA:Compara.
 GO:0006974; P:response to DNA damage stimulus; IEA:Compara. 
Interpro
 IPR003323; OTU.
 IPR019400; Peptidase_C65_otubain.
 IPR016615; Ubiquitin_thioesterase_Otubain. 
Pfam
 PF10275; Peptidase_C65 
SMART
  
PROSITE
 PS50802; OTU 
PRINTS