CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030691
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transducin-like enhancer protein 2 
Protein Synonyms/Alias
 cDNA FLJ61693, highly similar to Transducin-like enhancer protein 2 
Gene Name
 TLE2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
148TGGKGCVKVWDVGQPubiquitination[1]
177DNYIRSCKLLPDGRSubiquitination[1]
207AAPTPRIKAELTSSAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 410 AA 
Protein Sequence
MTFPPALLPP NPVTPPRPRT LPPPGPARPV TSASLLPSQH LPRTASVSSS VVYGRSPVMA 60
FESHPHLRGS SVSSSLPSIP GGKPAYSFHV SADGQMQPVP FPSDALVGAG IPRHARQLHT 120
LAHGEVVCAV TISGSTQHVY TGGKGCVKVW DVGQPGAKTP VAQLDCLNRD NYIRSCKLLP 180
DGRSLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AVSPDAKVCF SCCSDGNIVV 240
WDLQNQTMVR QFQGHTDGAS CIDISDYGTR LWTGGLDNTV RCWDLREGRQ LQQHDFSSQI 300
FSLGHCPNQD WLAVGMESSN VEILHVRKPE KYQLHLHESC VLSLKFASCG RWFVSTGKDN 360
LLNAWRTPYG ASIFQSKESS SVLSCDISRN NKYIVTGSGD KKATVYEVVY 410 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR009146; Groucho_enhance.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR01850; GROUCHOFAMLY.