CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025462
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sema domain, seven thrombospondin repeats (Type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (Semaphorin) 5A, isoform CRA_a 
Protein Synonyms/Alias
 Semaphorin-5A 
Gene Name
 Sema5a 
Gene Synonyms/Alias
 mCG_141513 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1027NHINKLDKYDSVEAIubiquitination[1]
1035YDSVEAIKAFNKNNLubiquitination[1]
1039EAIKAFNKNNLILEEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1074 AA 
Protein Sequence
MKGACILAWL FSSLGVWRLA RPETQDPAKC QRAEHPVVSY KEIGPWLREF RAENAVDFSR 60
LTFDPGQKEL VVGARNYLFR LELEDLSLIQ AVEWECDEAT KKACYSKGKS KEECQNYIRV 120
LLVGGDRLFT CGTNAFTPVC TIRSLSNLTE IHDQISGMAR CPYSPQHNST ALLTASGELY 180
AATAMDFPGR DPAIYRSLGT LPPLRTAQYN SKWLNEPNFV SSYDIGNFTY FFFRENAVEH 240
DCGKTVFSRA ARVCKNDIGG RFLLEDTWTT FMKARLNCSR PGEVPFYYNE LQGTFFLPEL 300
DLIYGIFTTN VNSIAASAVC VFNLSAISQA FNGPFKYQEN SRSAWLPYPN PNPNFQCGTM 360
DQGLYVNLTE RNLQDAQKFI LMHEVVQPVT TVPSFMEDNS RFSHLAVDVV QGRETLVHII 420
YLATDYGTIK KVRAPLSQSS GSCLLEEIEL FPERRSEPIR SLQILHSQSV LFVGLQEHVA 480
KIPLKRCHFH QTRSACIGAQ DPYCGWDAVM KKCTSLEESL SMTQWDQSIP TCPTRNLTVD 540
GSFGPWSPWT PCTHTDGTAV GSCLCRSRSC DSPAPQCGGW QCEGPRMEIT NCSRNGGWTP 600
WTSWSPCSTT CGIGFQVRQR SCSNPTPRHG GRVCVGQNRE ERYCNEHLLC PPHVFWTGWG 660
PWERCTAQCG GGIQARRRTC ENGPDCAGCN VEYQPCNTNA CPELKKTTPW TPWTPVNISD 720
NGGHYEQRFR YTCKARLPDP NLLEVGRQRI EMRYCSSDGT SGCSTDGLSG DFLRAGRYSA 780
HTVNGAWSAW TSWSQCSRDC SRGIRNRKRV CNNPEPKFGG MPCLGPSLEF QECNILPCPV 840
DGVWSCWSSW SKCSATCGGG HYMRTRSCSN PAPAYGGDIC LGLHTEEALC NTQTCPESWS 900
EWSDWSVCDA SGTQVRARQC ILLFPVGSQC SGNTTESRPC VFDSNFIPEV SVARSSSVEE 960
KRCGEFNMFH MMAVGLSSSI LGCLLTLLVY TYCQRYQQQS HDATVIHPVS PAALNSSITN 1020
HINKLDKYDS VEAIKAFNKN NLILEERNKY FNPHLTGKTY SNAYFTDLNN YDEY 1074 
Gene Ontology
 GO:0016021; C:integral to membrane; IDA:MGI.
 GO:0008046; F:axon guidance receptor activity; IDA:MGI.
 GO:0001569; P:patterning of blood vessels; IMP:MGI. 
Interpro
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002165; Plexin_repeat.
 IPR027231; Semaphorin.
 IPR001627; Semaphorin/CD100_Ag.
 IPR000884; Thrombospondin_1_rpt.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF01437; PSI
 PF01403; Sema
 PF00090; TSP_1 
SMART
 SM00423; PSI
 SM00630; Sema
 SM00209; TSP1 
PROSITE
 PS51004; SEMA
 PS50092; TSP1 
PRINTS