CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038818
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Indoleamine 2,3-dioxygenase 1 
Protein Synonyms/Alias
  
Gene Name
 Ido1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
215AASLEKAKEIFKRMRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 407 AA 
Protein Sequence
MPHSQISPAE GSRRILEEYH IDEDVGFALP HPLEELPDTY RPWILVARNL PKLIENGKLR 60
EEVEKLPTLR TEELRGHRLQ RLAHLALGYI TMAYVWNRGD DDIRKVLPRN LAVPYCELSE 120
KLGLPPILSY ADCVLANWKK KDPNGPMTYE NMDILFSFPG GDCDKGFFLV SLMVEIAASP 180
AIKAIPTVSS AVEHQDPKAL EKALCSIAAS LEKAKEIFKR MRDFVDPDTF FHVLRIYLSG 240
WKGNPKLPEG LLYEGVWDTP KKFSGGSAGQ SSIFQSLDVL LGIKHDVGEG SAAEFLQEMR 300
EYMPPAHRNF LSSLESAPPV REFVILRRNE DLKKAYNECV NGLVSLRMFH LSIVDTYIVK 360
PSKQKPMGGH KSEEPSNTEN RGTGGTDVMN FLRSVKDTTK KALLSWP 407 
Gene Ontology
 GO:0030485; C:smooth muscle contractile fiber; IEA:Compara.
 GO:0032421; C:stereocilium bundle; IEA:Compara.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0004833; F:tryptophan 2,3-dioxygenase activity; IEA:Compara.
 GO:0007610; P:behavior; IEA:Compara.
 GO:0002534; P:cytokine production involved in inflammatory response; IEA:Compara.
 GO:0034276; P:kynurenic acid biosynthetic process; IEA:Compara.
 GO:0033555; P:multicellular organismal response to stress; IEA:Compara.
 GO:0046007; P:negative regulation of activated T cell proliferation; IEA:Compara.
 GO:0032693; P:negative regulation of interleukin-10 production; IEA:Compara.
 GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0002678; P:positive regulation of chronic inflammatory response; IEA:Compara.
 GO:0032735; P:positive regulation of interleukin-12 production; IEA:Compara.
 GO:0002666; P:positive regulation of T cell tolerance induction; IEA:Compara.
 GO:0002830; P:positive regulation of type 2 immune response; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:Compara. 
Interpro
 IPR000898; Indolamine_dOase. 
Pfam
 PF01231; IDO 
SMART
  
PROSITE
 PS00876; IDO_1
 PS00877; IDO_2 
PRINTS