UniProt Accession

 RUSD1_HUMAN; Q9UJJ7; D3DU66 

Genbank Protein ID

 AE006465; AL031033; CH471112; CH471112; CH471112; BC011783 

Genbank Nucleotide ID

 AAK61255.1; CAB53055.1; EAW85712.1; EAW85713.1; EAW85715.1; AAH11783.1 

Protein Name

 RNA pseudouridylate synthase domain-containing protein 1 

Protein Synonyms/Alias

 Ribosomal large subunit pseudouridine synthase C-like protein 

Gene Name

 RPUSD1 

Gene Synonyms/Alias

 C16orf40; RLUCL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	WDVRIDSKAWRETLT	ubiquitination	[1]
42	RETLTLQKQLRYRFP	ubiquitination	[1]
97	FKERRVTKAYLALLR	ubiquitination	[1, 2]
167	PVSKVLLKPLTGRTH	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 ACT_SITE 67 67 By similarity.  

Keyword

 Complete proteome; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0001522; P:pseudouridine synthesis; IEA:InterPro. 

Interpro

 IPR020103; PsdUridine_synth_cat_dom.
 IPR006145; PsdUridine_synth_RsuA/RluD. 

Pfam

 PF00849; PseudoU_synth_2 

SMART

  

PROSITE

 PS01129; PSI_RLU 

PRINTS