CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021259
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Deoxynucleotidyltransferase terminal-interacting protein 1 
Protein Synonyms/Alias
 Terminal deoxynucleotidyltransferase-interacting factor 1; TdIF1; TdT-interacting factor 1 
Gene Name
 DNTTIP1 
Gene Synonyms/Alias
 C20orf167; TDIF1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43NPWNIMIKHRQVQRRubiquitination[1]
88EIQTVFNKYMKFFQKubiquitination[2]
91TVFNKYMKFFQKAALubiquitination[2]
95KYMKFFQKAALNVRDubiquitination[2, 3, 4]
126RSCLEQAKLLFSDGEubiquitination[2]
134LLFSDGEKVIPRLTHubiquitination[2, 3, 4]
147THELPGIKRGRQAEEubiquitination[2]
188AAAGMVWKPKSCEPIubiquitination[2]
249YAADPQDKHWLAEQHubiquitination[2]
306LPSWMVEKMRKYMETubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Shown to enhance TdT activity, in vitro. 
Sequence Annotation
 MOTIF 164 170 Nuclear localization signal (Potential).
 MOD_RES 161 161 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 329 AA 
Protein Sequence
MGATGDAEQP RGPSGAERGG LELGDAGAAG QLVLTNPWNI MIKHRQVQRR GRRSQMTTSF 60
TDPAISMDLL RAVLQPSINE EIQTVFNKYM KFFQKAALNV RDNVGEEVDA EQLIQEACRS 120
CLEQAKLLFS DGEKVIPRLT HELPGIKRGR QAEEECAHRG SPLPKKRKGR PPGHILSSDR 180
AAAGMVWKPK SCEPIRREGP KWDPARLNES TTFVLGSRAN KALGMGGTRG RIYIKHPHLF 240
KYAADPQDKH WLAEQHHMRA TGGKMAYLLI EEDIRDLAAS DDYRGCLDLK LEELKSFVLP 300
SWMVEKMRKY METLRTENEH RAVEAPPQT 329 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR026064; TdIF1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS