UniProt Accession

 MYL3_MOUSE; P09542; Q3UIF4; Q9CQZ2 

Genbank Protein ID

 AK002312; AK011518; AK146943; BC061222; X12972 

Genbank Nucleotide ID

 BAB22006.1; BAB27672.1; BAE27552.1; AAH61222.1; CAA31415.1 

Protein Name

 Myosin light chain 3 

Protein Synonyms/Alias

 Myosin light chain 1, slow-twitch muscle B/ventricular isoform; MLC1SB; Ventricular/slow twitch myosin alkali light chain 

Gene Name

 Myl3 

Gene Synonyms/Alias

 Mlc1v; Mylc 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	DAKAAAPKAAPAPAA	ubiquitination	[1]
42	APEPERPKEAEFDAS	ubiquitination	[1]
50	EAEFDASKIKIEFTP	ubiquitination	[1]
52	EFDASKIKIEFTPEQ	ubiquitination	[1]
75	LLFDRTPKGEMKITY	ubiquitination	[1]
79	RTPKGEMKITYGQCG	ubiquitination	[1]
107	EVLRVLGKPKQEELN	ubiquitination	[1]
109	LRVLGKPKQEELNSK	acetylation	[2]
109	LRVLGKPKQEELNSK	ubiquitination	[1]
132	PMLQHISKNKDTGTY	ubiquitination	[1]
134	LQHISKNKDTGTYED	ubiquitination	[1]
151	EGLRVFDKEGNGTVM	ubiquitination	[1]
180	LTEDEVEKLMAGQED	ubiquitination	[1]
199	INYEAFVKHIMAS**	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 Regulatory light chain of myosin. Does not bind calcium. 

Sequence Annotation

 DOMAIN 58 95 EF-hand 1.
 DOMAIN 137 172 EF-hand 2.
 DOMAIN 172 204 EF-hand 3.
 MOD_RES 2 2 N,N,N-trimethylalanine; by NTM1.  

Keyword

 Complete proteome; Methylation; Motor protein; Muscle protein; Myosin; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0031672; C:A band; IEA:Compara.
 GO:0031674; C:I band; IEA:Compara.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0003774; F:motor activity; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0006942; P:regulation of striated muscle contraction; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IEA:Compara.
 GO:0007519; P:skeletal muscle tissue development; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom. 

Pfam

 PF13405; EF_hand_4 

SMART

  

PROSITE

 PS50222; EF_HAND_2 

PRINTS