CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039620
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear receptor subfamily 4 group A member 1 
Protein Synonyms/Alias
  
Gene Name
 NR4A1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
435DSGPSTAKLDYSKFQubiquitination[1]
590NRIASCLKEHVAAVAubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 652 AA 
Protein Sequence
MTSAQYKIKI LIEGLHHGQR PGPAPPRQPG SFCWALKADG IMWLAKACWS IQSEMPCIQA 60
QYGTPAPSPG PRDHLASDPL TPEFIKPTMD LASPEAAPAA PTALPSFSTF MDGYTGEFDT 120
FLYQLPGTVQ PCSSASSSAS STSSSSATSP ASASFKFEDF QVYGCYPGPL SGPVDEALSS 180
SGSDYYGSPC SAPSPSTPSF QPPQLSPWDG SFGHFSPSQT YEGLRAWTEQ LPKASGPPQP 240
PAFFSFSPPT GPSPSLAQSP LKLFPSQATH QLGEGESYSM PTAFPGLAPT SPHLEGSGIL 300
DTPVTSTKAR SGAPGGSEGR CAVCGDNASC QHYGVRTCEG CKGFFKRTVQ KNAKYICLAN 360
KDCPVDKRRR NRCQFCRFQK CLAVGMVKEV VRTDSLKGRR GRLPSKPKQP PDASPANLLT 420
SLVRAHLDSG PSTAKLDYSK FQELVLPHFG KEDAGDVQQF YDLLSGSLEV IRKWAEKIPG 480
FAELSPADQD LLLESAFLEL FILRLAYRSK PGEGKLIFCS GLVLHRLQCA RGFGDWIDSI 540
LAFSRSLHSL LVDVPAFACL SALVLITDRH GLQEPRRVEE LQNRIASCLK EHVAAVAGEP 600
QPASCLSRLL GKLPELRTLC TQGLQRIFYL KLEDLVPPPP IIDKIFMDTL PF 652 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030522; P:intracellular receptor signaling pathway; IEA:GOC. 
Interpro
 IPR003071; Nuc_orp_HMR_rcpt.
 IPR003070; Nuc_orph_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR01285; HMRNUCRECPTR.
 PR01284; NUCLEARECPTR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.