| Tag | Content |
|---|
| CPLM ID | CPLM-013156 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TBC1 domain family member 24 |
Protein Synonyms/Alias | |
Gene Name | Tbc1d24 |
Gene Synonyms/Alias | Kiaa1171 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 80 | VYSDIVGKIVGKHSS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. |
Sequence Annotation | DOMAIN 45 236 Rab-GAP TBC.
DOMAIN 368 556 TLD. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; GTPase activation; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 561 AA |
Protein Sequence | MDPPGYNCFV DKDKMDASIQ DLGPKELNCT ELQELKQLAR QGYWAQSHTL RGKVYQRLIR 60
DIPCRTVTPD ASVYSDIVGK IVGKHSSSSL PLPEFVDNTQ VPTYCLNTRG EGAVRKILLC 120
IANQFPDISF CPALPAVVAL LLHYSIDEAE CFEKACRILS CNDPTKKLID QSFLAFESSC 180
MTFGDLVNKY CQAAHKLMVA VSEDVLQVYS DWQRWLFGEL PLNYFARVFD VFLVEGYKVL 240
YRVALAILKF FHKVRAGQPL ESDNVKQDIR MFVKDIAKTV SPEKLLEKAF AIRLFSRKEI 300
QLLQMANEKA LRQKGITVKQ KSVSLSKRQF VHLAVHAENF HSEIVSVKEM RDIWSWIPER 360
FALCQPLLLF SSLQHGYSLS RFYFQCEGHE PTLLLIKTTQ KEVCGAYLST DWSERTKFGG 420
KLGFFGTGEC FVFRLQPEVQ RYEWVVIKHP ELTKATSLKS SEAAGSSSLI SHCSSDPADR 480
LSPFLAARHF NLPSKTESMF MAGGNDCLII GGGGGQALYV DGDLNRGRTG HCDTFNNQPL 540
CSENFLIAAV EAWGFQDPDT E 561 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005097; F:Rab GTPase activator activity; IEA:InterPro. GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |