CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044923
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Hsp90 co-chaperone Cdc37 
Protein Synonyms/Alias
  
Gene Name
 CDC37 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67KVAECQRKLKELEVAubiquitination[1]
69AECQRKLKELEVAEGubiquitination[1, 2, 3]
78LEVAEGGKAELERLQacetylation[3, 4, 5]
101EERSWEQKLEEMRKKubiquitination[1, 6]
110EEMRKKEKSMPWNVDubiquitination[2, 6]
121WNVDTLSKDGFSKAHubiquitination[1, 6]
205KHKTFVEKYEKQIKHacetylation[3, 4, 5]
208TFVEKYEKQIKHFGMacetylation[3]
208TFVEKYEKQIKHFGMubiquitination[1]
311NDELEAFKERVRGRAubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 353 AA 
Protein Sequence
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK 60
VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS 120
KDGFSKAHAH APATLMLMAS SPPPPWMGWA LRPRPARPRS RRSAALPQPT PPLTLPQSMV 180
NTKPEKTEED SEEVREQKHK TFVEKYEKQI KHFGMLRRWD DSQKYLSDNV HLVCEETANY 240
LVIWCIDLEV EEKCALMEQV AHQTIVMQFI LELAKSLKVD PRACFRQFFT KIKTADRQYM 300
EGFNDELEAF KERVRGRAKL RIEKAMKEYE EEERKKRLGP GGLDPVEVYE SLP 353 
Gene Ontology
  
Interpro
 IPR004918; Cdc37.
 IPR013874; Cdc37_Hsp90-bd.
 IPR013855; Cdc37_N_dom. 
Pfam
 PF08565; CDC37_M
 PF03234; CDC37_N 
SMART
 SM01070; CDC37_M
 SM01071; CDC37_N 
PROSITE
  
PRINTS