UniProt Accession

 E9Q1V0_MOUSE; E9Q1V0 

Genbank Protein ID

 AC109153 

Genbank Nucleotide ID

  

Protein Name

 Hsc70-interacting protein 

Protein Synonyms/Alias

  

Gene Name

 St13 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
80	MDEANEKKGAAIEAL	ubiquitination	[1]
104	DLFTDAIKLNPRLAI	ubiquitination	[1]
115	RLAILYAKRASVFVK	acetylation	[2, 3, 4, 5]
115	RLAILYAKRASVFVK	phosphoglycerylation	[6]
115	RLAILYAKRASVFVK	succinylation	[5]
115	RLAILYAKRASVFVK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 129 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0032564; F:dATP binding; IEA:Compara.
 GO:0070389; P:chaperone cofactor-dependent protein refolding; IEA:Compara.
 GO:0061084; P:negative regulation of protein refolding; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara. 

Interpro

 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical. 

Pfam

  

SMART

  

PROSITE

 PS50293; TPR_REGION 

PRINTS