CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010890
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ets DNA-binding protein pokkuri 
Protein Synonyms/Alias
 Protein anterior open; Protein yan 
Gene Name
 aop 
Gene Synonyms/Alias
 pok; Yan; CG3166 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
665ADGLTTIKLIRYNEHacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Negative regulator of photoreceptor development that acts antagonistically to the proneural signal mediated by RAS. It acts upstream of SINA to inhibit R7 development. 
Sequence Annotation
 DOMAIN 33 117 PNT.
 DNA_BIND 396 479 ETS.
 MOD_RES 543 543 Phosphoserine.
 MOD_RES 677 677 Phosphoserine.
 MOD_RES 682 682 Phosphoserine.
 MOD_RES 696 696 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Developmental protein; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 732 AA 
Protein Sequence
MSKMKMLPVQ LSLNSLNPGI WSDVLWRCPP APSSQLAELK TQLPPSLPSD PRLWSREDVL 60
VFLRFCVREF DLPKLDFDLF QMNGKALCLL TRADFGHRCP GAGDVLHNVL QMLIIESHMM 120
QWHLPNSPVT PTSRYPLSPH SHPPTPTWPP LNAPPENSPF HSSAHSLAGH HFMAPNSVTL 180
SPPPSVDSQA SSPPQAPYQN GGATGAAPGS AGGSAPAAGG ATNTSNPTSS SASSTGSNGS 240
QPNIMPMKGI SSASSNHSDS EEEYSETSGG VSKMPPAPLS YSTASPPGTP ILKDIKPNWT 300
QQLTNSFVNS WSQQQQQQQQ QQAAAVAAVA AQAQQHQLQQ QQQQQQLPQK LTLDNTAGPV 360
VTPAGGSISA PTTPSYMYKA KREFFPENSE PNTNGRLLWD FLQQLLNDRN QKYSDLIAWK 420
CRDTGVFKIV DPAGLAKLWG IQKNHLSMNY DKMSRALRYY YRVNILRKVQ GERHCYQFLR 480
NPTELKNIKN ISLLRQSTPA NGNGGSPSMP QGSSQAPGSP AGQNWNPQQQ SQQQQQSPQR 540
PASRNGPMSL PAVAAVAAAA AAAYGPPPTS PLFMHAINGA FHYLSAAAAG PPPNSPALNT 600
PSAVGGPDKF QFHPLKLENG SGSGSESAGE DLKPTDLSVS SKSTATSNED CYPLIRNADG 660
LTTIKLIRYN EHQVAASPAG QSPKHDDQQA GASNASSSPR PMDQASEQAQ PVPMESDCNG 720
GESEDSFRHM QQ 732 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:FlyBase.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0007298; P:border follicle cell migration; IMP:FlyBase.
 GO:0001709; P:cell fate determination; IMP:FlyBase.
 GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
 GO:0007391; P:dorsal closure; NAS:FlyBase.
 GO:0006897; P:endocytosis; IMP:FlyBase.
 GO:0008406; P:gonad development; IMP:FlyBase.
 GO:0006917; P:induction of apoptosis; IMP:FlyBase.
 GO:0007254; P:JNK cascade; NAS:FlyBase.
 GO:0048747; P:muscle fiber development; IMP:FlyBase.
 GO:0007517; P:muscle organ development; IMP:FlyBase.
 GO:0046533; P:negative regulation of photoreceptor cell differentiation; TAS:FlyBase.
 GO:0046580; P:negative regulation of Ras protein signal transduction; NAS:FlyBase.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:FlyBase.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IMP:FlyBase.
 GO:0060233; P:oenocyte delamination; IMP:FlyBase.
 GO:0045678; P:positive regulation of R7 cell differentiation; IGI:FlyBase.
 GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
 GO:0045467; P:R7 cell development; TAS:FlyBase.
 GO:0090175; P:regulation of establishment of planar polarity; IGI:FlyBase.
 GO:0045610; P:regulation of hemocyte differentiation; IMP:FlyBase. 
Interpro
 IPR000418; Ets_dom.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00178; Ets
 PF02198; SAM_PNT 
SMART
 SM00413; ETS
 SM00251; SAM_PNT 
PROSITE
 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 
PRINTS
 PR00454; ETSDOMAIN.